Health services research in patients with breast cancer (CAMISS-prospective): study protocol for an observational prospective study

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• dc.contributor.author García Gutiérrez, Susanaca
• dc.contributor.author Orive, Mirenca
• dc.contributor.author Sarasqueta, Cristinaca
• dc.contributor.author Legarreta, Maria Joséca
• dc.contributor.author González, Nereaca
• dc.contributor.author Redondo, Maximinoca
• dc.contributor.author Rivero, Amadoca
• dc.contributor.author Serrano-Aguilar, Pedroca
• dc.contributor.author Castells, Xavierca
• dc.contributor.author Quintana, José Maríaca
• dc.contributor.author Sala Serra, Mariaca
• dc.contributor.author REDISSEC-CaMISS Groupca
• dc.date.accessioned 2018-10-15T07:57:24Z
• dc.date.available 2018-10-15T07:57:24Z
• dc.date.issued 2018
• dc.description.abstract BACKGROUND: Though breast cancer remains a major health problem, there is a lack of information on health care provided to patients with this disease and associated costs. In addition, there is a need to update and validate risk stratification tools in Spain. Our purpose is to evaluate the health services provided for breast cancer in Spain, from screening and diagnosis to treatment and prognosis. METHODS: Prospective cohort study involving 13 hospitals in Spain with a follow-up period of up to 5 years after diagnostic biopsy. Eligibility criteria: Patients diagnosed with breast cancer between April 2013 and May 2015 that have consented to participate in the study. DATA COLLECTION: Data will be collected on the following: pre-intervention medical history, biological, clinical, and sociodemographic characteristics, mode of cancer detection, hospital admission, treatment, and outcomes up to 5 years after initial treatment. Questionnaires about quality of life (EuroQoL EQ-5D-5 L, the European Organization For Research And Treatment Of Cancer Core Quality Of Life Questionnaire EORTC QLQ-C30 join to the specific breast cancer module (QLQ-BR23), as well as Hospital Anxiety and Depression Scale were completed by the patients before the beginning of the initial treatment and at the end of follow-up period, 2 years later. The end-points of the study were changes in health-related quality of life, recurrence, complications and readmissions at 2 and 5 years after initial treatment. STATISTICAL ANALYSIS: Descriptive statistics will be calculated and multivariate models will be used where appropriate to adjust for potential confounders. In order to create and validate a prediction model, split validation and bootstrapping will be performed. Cost analysis will be carried out from the perspective of a national health system. DISCUSSION: The results of this coordinated project are expected to generate scientifically valid and clinically and socially important information to inform the decision-making of managers and the authorities responsible for ensuring equality in care processes as well in health outcomes. For clinicians, clinical prediction rules will be developed which are expected to serve as the basis for the development of software applications.
• dc.format.mimetype application/pdf
• dc.identifier.citation García-Gutierrez S, Orive M, Sarasqueta C, Legarreta MJ, Gonzalez N, Redondo M. et al. Health services research in patients with breast cancer (CAMISS-prospective): study protocol for an observational prospective study.BMC Cancer. 2018 Jan 8;18(1):54. DOI: 10.1186/s12885-017-3926-9
• dc.identifier.doi http://dx.doi.org/10.1186/s12885-017-3926-9
• dc.identifier.issn 1471-2407
• dc.identifier.uri http://hdl.handle.net/10230/35608
• dc.language.iso eng
• dc.publisher BioMed Centralca
• dc.relation.ispartof BMC Cancer. 2018 Jan 8;18(1):54
• dc.rights Copyright © The Author(s). 2018. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Breast cancer
• dc.subject.keyword Clinical prediction rules
• dc.subject.keyword Health services research
• dc.subject.other Mama -- Càncer
• dc.title Health services research in patients with breast cancer (CAMISS-prospective): study protocol for an observational prospective studyca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion