Urban upbringing and childhood respiratory and allergic conditions: A multi-country holistic study

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• dc.contributor.author Tischer, Christina
• dc.contributor.author Dadvand, Payam
• dc.contributor.author Basagaña Flores, Xavier
• dc.contributor.author Sunyer Deu, Jordi
• dc.contributor.author Antó i Boqué, Josep Maria
• dc.date.accessioned 2019-05-16T07:28:10Z
• dc.date.issued 2018
• dc.description.abstract Objective: We integratively assessed the effect of different indoor and outdoor environmental exposures early in life on respiratory and allergic health conditions among children from (sub-) urban areas. Methods: This study included children participating in four ongoing European birth cohorts located in three different geographical regions: INMA (Spain), LISAplus (Germany), GINIplus (Germany) and BAMSE (Sweden). Wheezing, bronchitis, asthma and allergic rhinitis throughout childhood were assessed using parental-completed questionnaires. We designed “environmental scores” corresponding to different indoor, green- and grey-related exposures (main analysis, a-priori-approach). Cohort-specific associations between these environmental scores and the respiratory health outcomes were assessed using random-effects meta-analyses. In addition, a factor analysis was performed based on the same exposure information used to develop the environmental scores (confirmatory analysis, data-driven-approach). Results: A higher early exposure to the indoor environmental score increased the risk for wheezing and bronchitis within the first year of life (combined adjusted odds ratio: 1.20 [95% confidence interval: 1.13–1.27] and 1.28 [1.18–1.39], respectively). In contrast, there was an inverse association with allergic rhinitis between 6 and 8 years (0.85 [0.79–0.92]). There were no statistically significant associations for the outdoor related environmental scores in relation to any of the health outcomes tested. The factor analysis conducted confirmed these trends. Conclusion: Although a higher exposure to indoor related exposure through occupants was associated with an increased risk for wheezing and bronchitis within the 1st year, it might serve as a preventive mechanism against later childhood allergic respiratory outcomes in urbanized environments through enhanced shared contact with microbial agents.
• dc.description.sponsorship This study was funded by Grants from UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), and from Spain: Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647, 11/0178, 11/01007, 11/02591, 11/02038, 13/1944, 13/2032, 14/0891, and 14/1687) and the Conselleria de Sanitat, Generalitat Valenciana. The BAMSE study has been supported by the Swedish Research Council, the Swedish Heart-Lung Foundation, the Swedish Research Council Formas, the Swedish Environment Protection Agency, the European Community's Seventh Framework Program (FP7/2007–2011 under grant agreement no. 211250), the Swedish Asthma and Allergy Association Research Foundation, and the Stockholm County Council. Christina Tischer is a recipient of a European Respiratory Society Fellowship (RESPIRE2 – 2015– 7251). Payam Dadvand is funded by a Ramón y Cajal fellowship (RYC-2012-10995) awarded by the Spanish Ministry of Economy and Competitiveness. Elaine Fuertes is supported by a Marie Skłodowska-Curie Individual Fellowship (H2020-MSCA-IF-2015; proposal number 704268).
• dc.format.mimetype application/pdf
• dc.identifier.citation Tischer C, Dadvand P, Basagana X, Fuertes E, Bergström A, Gruzieva O et al. Urban upbringing and childhood respiratory and allergic conditions: A multi-country holistic study. Environ Res. 2018;161:276-83. DOI: 10.1016/j.envres.2017.11.013
• dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2017.11.013
• dc.identifier.issn 0013-9351
• dc.identifier.uri http://hdl.handle.net/10230/37235
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environmental Research. 2018;161:276-83
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/704268
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.envres.2017.11.013
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Indoor exposure
• dc.subject.keyword Microbial load
• dc.subject.keyword Green space
• dc.subject.keyword Grey space
• dc.subject.keyword Asthma
• dc.subject.keyword Allergic rhinitis
• dc.title Urban upbringing and childhood respiratory and allergic conditions: A multi-country holistic study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion