The 5' untranslated region of the serotonin receptor 2C pre-mRNA generates miRNAs and is expressed in non-neuronal cells

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• dc.contributor.author Zhang, Zhaiyica
• dc.contributor.author Falaleeva, Marinaca
• dc.contributor.author Agranat-Tamir, Lilyca
• dc.contributor.author Pagès Pinós, Amadísca
• dc.contributor.author Eyras Jiménez, Eduardoca
• dc.contributor.author Sperling, Josephca
• dc.contributor.author Sperling, Ruthca
• dc.contributor.author Stamm, Stefanca
• dc.date.accessioned 2015-11-27T19:29:11Z
• dc.date.available 2015-11-27T19:29:11Z
• dc.date.issued 2013
• dc.description.abstract The serotonin receptor 2C (HTR2C) gene encodes a G protein-coupled receptor that is exclusively expressed in neurons. Here, we report that the 5' untranslated region of the receptor pre-mRNA as well as its hosted miRNAs is widely expressed in non-neuronal cell lines. Alternative splicing of HTR2C is regulated by MBII-52. MBII-52 and the neighboring MBII-85 cluster are absent in people with Prader-Willi syndrome, which likely causes the disease. We show that MBII-52 and MBII-85 increase expression of the HTR2C 5' UTR and influence expression of the hosted miRNAs. The data indicate that the transcriptional unit expressing HTR2C is more complex than previously recognized and likely deregulated in Prader-Willi syndrome.ca
• dc.description.sponsorship This work was supported by NIH RO1 GM083187, P20RR020171 to SS; GM079549 to RS and JS; Binational Science Foundation (BSF), USA-Israel, transformative Grant, #2010508, to SS and RS. EE and AP were supported by the Spanish Ministry of Science with grant BIO2011-23920 and by Sandra Ibarra Foundation for Cancer with grant FSI 2011-035
• dc.format.mimetype application/pdfca
• dc.identifier.citation Zhang Z, Falaleeva M, Agranat-Tamir L, Pages A, Eyras E, Sperling J et al. The 5' untranslated region of the serotonin receptor 2C pre-mRNA generates miRNAs and is expressed in non-neuronal cells. Experimental brain research. 2013. 230(4): 387-394. DOI 10.1007/s00221-013-3458-8ca
• dc.identifier.doi http://dx.doi.org/10.1007/s00221-013-3458-8
• dc.identifier.issn 0014-4819
• dc.identifier.uri http://hdl.handle.net/10230/25259
• dc.language.iso engca
• dc.publisher Springer Verlagca
• dc.relation.ispartof Experimental brain research. 2013. 230(4): 387-394
• dc.rights © The Author(s) 2013. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.other Regulació genèticaca
• dc.subject.other RNAca
• dc.subject.other Serotonina -- Receptorsca
• dc.title The 5' untranslated region of the serotonin receptor 2C pre-mRNA generates miRNAs and is expressed in non-neuronal cellsca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca