Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network

Blume, Julia von; Alleaume, Anne-Marie; Kienzle, Christine; Carreras Sureda, Amado, 1986-; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek

Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network

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dc.contributor.author Blume, Julia vonca
dc.contributor.author Alleaume, Anne-Marieca
dc.contributor.author Kienzle, Christineca
dc.contributor.author Carreras Sureda, Amado, 1986-ca
dc.contributor.author Valverde, M. A. (Miguel Ángel), 1963-ca
dc.contributor.author Malhotra, Vivekca
dc.date.accessioned 2014-05-08T09:16:59Z
dc.date.available 2014-05-08T09:16:59Z
dc.date.issued 2012ca
dc.description.abstract Ca(2+) import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca(2+) retained in the lumen of the Golgi, and what is its role in cargo sorting? We show here that a soluble, lumenal Golgi resident protein, Cab45, is required for SPCA1-dependent Ca(2+) import into the TGN; it binds secretory cargo in a Ca(2+)-dependent reaction and is required for its sorting at the TGN.
dc.description.sponsorship V. Malhotra is an Institució Catalana de Recerca i Estudis Avançats (ICREA) professor at the Center for Genomic Regulation, and the work in his laboratory is funded by grants from Plan Nacional (BFU2008-00414), Consolider (CSD2009-00016), Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) Grups de Recerca Emergents (SGR2009-1488; AGAUR-Catalan Government), and the European Research Council (268692). The group of J. von Blume is funded by an Emmy Noether fellowship (project BL 1186/1-1) of the Deutsche Forschungsgemeinschaft (DFG). M.A. Valverde is the recipient of an ICREA Academia Award and the work in his laboratory is supported by the Spanish ministry of Science and Innovation (SAF2012-38140), Fondo de Investigación Sanitaria (RD12/0042/0014), FEDER Funds, and Generalitat de Catalunya (SGR05-266)
dc.format.mimetype application/pdfca
dc.identifier.citation von Blume J, Alleaume AM, Kienzle C, Carreras-Sureda A, Valverde M, Malhotra V. Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network. J Cell Biol. 2012;199(7):1057-66. DOI: 10.1083/jcb.201207180ca
dc.identifier.doi http://dx.doi.org/10.1083/jcb.201207180
dc.identifier.issn 0021-9525ca
dc.identifier.uri http://hdl.handle.net/10230/22475
dc.language.iso engca
dc.publisher Rockefeller University Pressca
dc.relation.ispartof Journal of cell biology. 2012;199(7):1057-66
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/268692ca
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2008-00414
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/CSD2009-00016
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SGR2009-1488
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-38140
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.rights.uri http://creativecommons.org/licenses/by/3.0/
dc.subject.other Aparell de Golgi
dc.subject.other Proteïnes
dc.title Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi networkca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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