Cell memory of epithelial-mesenchymal plasticity in cancer
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- dc.contributor.author Berenguer De Felipe, Jordi
- dc.contributor.author Celià-Terrassa, Toni
- dc.date.accessioned 2022-06-01T06:26:41Z
- dc.date.available 2022-06-01T06:26:41Z
- dc.date.issued 2021
- dc.description.abstract Fundamental biological processes of cell identity and cell fate determination are controlled by complex regulatory networks. These processes require molecular mechanisms that confer cellular phenotypic memory and state persistence. In this minireview, we will summarize mechanisms of cell memory based on regulatory hysteretic feedback loops and explore epigenetic mechanisms widely represented in nature, with special focus on epithelial-to-mesenchymal plasticity. We will also discuss the functional consequences of cell memory and epithelial-to-mesenchymal plasticity dynamics during development and cancer metastasis.
- dc.format.mimetype application/pdf
- dc.identifier.citation Berenguer J, Celià-Terrassa T. Cell memory of epithelial-mesenchymal plasticity in cancer. Curr Opin Cell Biol. 2021 Apr; 69: 103-10. DOI: 10.1016/j.ceb.2021.01.001
- dc.identifier.doi http://dx.doi.org/10.1016/j.ceb.2021.01.001
- dc.identifier.issn 0955-0674
- dc.identifier.uri http://hdl.handle.net/10230/53338
- dc.language.iso eng
- dc.publisher Elsevier
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.ceb.2021.01.001
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Cell plasticity
- dc.subject.keyword Cell state
- dc.subject.keyword Cellular memory
- dc.subject.keyword Dynamics
- dc.subject.keyword EMT
- dc.subject.keyword Feedback loops
- dc.subject.keyword Hysteresis
- dc.subject.keyword Multistability
- dc.title Cell memory of epithelial-mesenchymal plasticity in cancer
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion