AI-assisted proofreading of RNA splicing
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- dc.contributor.author Guerra Moreno, Ángel
- dc.contributor.author Valcárcel, J. (Juan)
- dc.date.accessioned 2024-02-13T07:19:03Z
- dc.date.available 2024-02-13T07:19:03Z
- dc.date.issued 2023
- dc.description.abstract RNA helicases orchestrate proofreading mechanisms that facilitate accurate intron removal from pre-mRNAs. How these activities are recruited to spliceosome/pre-mRNA complexes remains poorly understood. In this issue of Genes & Development, Zhang and colleagues (pp. 968-983) combine biochemical experiments with AI-based structure prediction methods to generate a model for the interaction between SF3B1, a core splicing factor essential for the recognition of the intron branchpoint, and SUGP1, a protein that bridges SF3B1 with the helicase DHX15. Interaction with SF3B1 exposes the G-patch domain of SUGP1, facilitating binding to and activation of DHX15. The model can explain the activation of cryptic 3' splice sites induced by mutations in SF3B1 or SUGP1 frequently found in cancer.
- dc.format.mimetype application/pdf
- dc.identifier.citation Guerra-Moreno Á, Valcárcel J. AI-assisted proofreading of RNA splicing. Genes Dev. 2023 Dec 26;37(21-24):945-7. DOI: 10.1101/gad.351373.123
- dc.identifier.doi http://dx.doi.org/10.1101/gad.351373.123
- dc.identifier.issn 0890-9369
- dc.identifier.uri http://hdl.handle.net/10230/59089
- dc.language.iso eng
- dc.publisher Cold Spring Harbor Laboratory Press (CSHL Press)
- dc.relation.ispartof Genes Dev. 2023 Dec 26;37(21-24):945-7
- dc.rights © 2023 Guerra-Moreno and Valcárcel; Published by Cold Spring Harbor Laboratory Press. This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.subject.keyword AlphaFold-Multimer
- dc.subject.keyword DHX15
- dc.subject.keyword G-patch
- dc.subject.keyword Myelodysplastic syndromes
- dc.subject.keyword Spliceosome mutations
- dc.title AI-assisted proofreading of RNA splicing
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion