The role of Nuclear factor I A (Nfia) during late embryonic neurogenesis
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- dc.contributor.author Río Bergé, Clàudia
- dc.date.accessioned 2021-01-08T09:27:25Z
- dc.date.available 2021-01-08T09:27:25Z
- dc.date.issued 2021
- dc.description Treball de fi de grau en Biologia Humanaca
- dc.description Supervisora: Cristina Pujades
- dc.description.abstract The Nuclear factor I A (Nfia) is a transcription factor which seems to be a key element during late embryonic brain neurogenesis. Since most of the studies about the role of Nfia in the Central Nervous System (CNS) are mainly focused on later stages, this project aims to shed light on the role of Nfia at embryonic stages. Firstly, I review the Nfia factor and its functions in the developing CNS. As there are hints that Nfia activity crosstalks with Notch signalling, I also review the Notch pathway and its operating mechanisms. Finally, I discuss the potential interplay between Nfia and Notch signalling. The main conclusions are that nfia is expressed in progenitor cells of the developing CNS, where it inhibits neurogenesis by promoting the maintenance of an undifferentiated pool of cells. These can give rise to late-born neurons. This role of maintaining cells in their undifferentiated state might be promoted by the synergy between Notch signalling and Nfia. Further studies are required in order to completely understand how this synergic mechanism is carried out. To finish this project, I propose several experiments in the context of zebrafish hindbrain which could help to answer some of the remaining questions.ca
- dc.format.mimetype application/pdf
- dc.identifier.uri http://hdl.handle.net/10230/46128
- dc.language.iso engca
- dc.rights Reconeixement-NoComercial-CompartirIgual 4.0 Internacional*
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/4.0/deed.ca*
- dc.subject.other Factors de transcripció
- dc.subject.other Neurobiologia del desenvolupament
- dc.subject.other Embriologia
- dc.subject.other Genètica
- dc.title The role of Nuclear factor I A (Nfia) during late embryonic neurogenesisca
- dc.type info:eu-repo/semantics/bachelorThesisca