Activation of viral defense signaling in cancer
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- dc.contributor.author Gonzalez-Cao, Maria
- dc.contributor.author Karachaliou, Niki
- dc.contributor.author Santarpia, Mariacarmela
- dc.contributor.author Viteri, Santiago
- dc.contributor.author Meyerhans, Andreas
- dc.contributor.author Rosell, Rafael
- dc.date.accessioned 2022-10-25T06:05:15Z
- dc.date.available 2022-10-25T06:05:15Z
- dc.date.issued 2018
- dc.description.abstract A coordinated action of innate and adaptive immune responses is required to efficiently combat a microbial infection. It has now become clear that cancer therapies also largely benefit when both arms of the immune response are engaged. In this review, we will briefly describe the current knowledge of innate immunity and how this can be utilized to prime tumors for a better response to immune checkpoint inhibitors. Comments on compounds in development and ongoing clinical trials will be provided.
- dc.description.sponsorship AM is supported by a grant from the Spanish Ministry of Economy, Industry and Compet-itiveness and FEDER grant no. SAF2016-75505-R (AEI/MINEICO/FEDER, UE), and the ‘María de Maeztu’ Programme for Units of Excellence in R&D (MDM-2014-0370). Work in Dr Rosell’s laboratory is partially supported by a grant from La Caixa Foundation, and by a European Grant (ELBA no 765492).
- dc.format.mimetype application/pdf
- dc.identifier.citation Gonzalez-Cao M, Karachaliou N, Santarpia M, Viteri S, Meyerhans A, Rosell R. Activation of viral defense signaling in cancer. Ther Adv Med Oncol. 2018 Jan-Dec;10:1–12. DOI: 10.1177/1758835918793105
- dc.identifier.doi http://dx.doi.org/10.1177/1758835918793105
- dc.identifier.issn 1758-8340
- dc.identifier.uri http://hdl.handle.net/10230/54560
- dc.language.iso eng
- dc.publisher SAGE Publications
- dc.relation.ispartof Therapeutic Advances in Medical Oncology. 2018 Jan-Dec;10:1–12
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/765492
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-75505-R
- dc.rights © The Author(s), 2018. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.subject.keyword Cancer immunotherapy
- dc.subject.keyword Innate immunity
- dc.subject.keyword TLRs
- dc.subject.keyword Viral defense signaling
- dc.title Activation of viral defense signaling in cancer
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion