Activation of viral defense signaling in cancer

Gonzalez-Cao, Maria; Karachaliou, Niki; Santarpia, Mariacarmela; Viteri, Santiago; Meyerhans, Andreas; Rosell, Rafael

doi:http://dx.doi.org/10.1177/1758835918793105

Activation of viral defense signaling in cancer

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Gonzalez-Cao M, Karachaliou N, Santarpia M, Viteri S, Meyerhans A, Rosell R. Activation of viral defense signaling in cancer. Ther Adv Med Oncol. 2018 Jan-Dec;10:1–12. DOI: 10.1177/1758835918793105

Abstract

A coordinated action of innate and adaptive immune responses is required to efficiently combat a microbial infection. It has now become clear that cancer therapies also largely benefit when both arms of the immune response are engaged. In this review, we will briefly describe the current knowledge of innate immunity and how this can be utilized to prime tumors for a better response to immune checkpoint inhibitors. Comments on compounds in development and ongoing clinical trials will be provided.