Changing trends in the global consumption of treatments used in hospitalized patients for COVID-19: a time series multicentre study

Aranda, Judit; Loureiro-Amigo, Jose; Murgadella-Sancho, Anna; Vàzquez, Núria; Feria, Lucía; Muñoz, Miriam; Padulles, Ariadna; Abelenda-Alonso, Gabriela; Garcia-Vidal, Carol; Tuset, Montserrat; Albanell, Marta; Boix Palop, Lucía; Sanmartí-Martínez, Núria; Gómez-Zorrilla, Silvia; Echeverría Esnal, Daniel; Rodríguez-Alarcón, Alicia; Borjabad, Beatriz; Coloma, Ana; Carratalà, Jordi; Oriol, Isabel

Changing trends in the global consumption of treatments used in hospitalized patients for COVID-19: a time series multicentre study

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dc.contributor.author Aranda, Judit
dc.contributor.author Loureiro-Amigo, Jose
dc.contributor.author Murgadella-Sancho, Anna
dc.contributor.author Vàzquez, Núria
dc.contributor.author Feria, Lucía
dc.contributor.author Muñoz, Miriam
dc.contributor.author Padulles, Ariadna
dc.contributor.author Abelenda-Alonso, Gabriela
dc.contributor.author Garcia-Vidal, Carol
dc.contributor.author Tuset, Montserrat
dc.contributor.author Albanell, Marta
dc.contributor.author Boix Palop, Lucía
dc.contributor.author Sanmartí-Martínez, Núria
dc.contributor.author Gómez-Zorrilla, Silvia
dc.contributor.author Echeverría Esnal, Daniel
dc.contributor.author Rodríguez-Alarcón, Alicia
dc.contributor.author Borjabad, Beatriz
dc.contributor.author Coloma, Ana
dc.contributor.author Carratalà, Jordi
dc.contributor.author Oriol, Isabel
dc.date.accessioned 2023-09-07T06:25:47Z
dc.date.available 2023-09-07T06:25:47Z
dc.date.issued 2023
dc.description.abstract Aim: To analyze trends in the prescription of COVID-19 treatments for hospitalized patients during the pandemic. Methods: Multicenter, ecological, time-series study of aggregate data for all adult patients with COVID-19 treated in five acute-care hospitals in Barcelona, Spain, between March 2020 and May 2021. Trends in the monthly prevalence of drugs used against COVID-19 were analyzed by the Mantel-Haenszel test. Results: The participating hospitals admitted 22,277 patients with COVID-19 during the study period, reporting an overall mortality of 10.8%. In the first months of the pandemic, lopinavir/ritonavir and hydroxychloroquine were the most frequently used antivirals, but these fell into disuse and were replaced by remdesivir in July 2020. By contrast, the trend in tocilizumab use varied, first peaking in April and May 2020, declining until January 2021, and showing a discrete upward trend thereafter. Regarding corticosteroid use, we observed a notable upward trend in the use of dexamethasone 6 mg per day from July 2020. Finally, there was a high prevalence of antibiotics use, especially azithromycin, in the first three months, but this decreased thereafter. Conclusions: Treatment for patients hospitalized with COVID-19 evolved with the changing scientific evidence during the pandemic. Initially, multiple drugs were empirically used that subsequently could not demonstrate clinical benefit. In future pandemics, stakeholders should strive to promote the early implementation of adaptive randomized clinical trials.
dc.format.mimetype application/pdf
dc.identifier.citation Aranda J, Loureiro-Amigo J, Murgadella A, Vàzquez N, Feria L, Muñoz M, Padulles A, Abelenda G, Garcia-Vidal C, Tuset M, Albanell M, Boix-Palop L, Sanmartí-Martínez N, Gómez-Zorrilla S, Echeverria-Esnal D, Rodriguez-Alarcón A, Borjabad B, Coloma A, Carratalà J, Oriol I. Changing trends in the global consumption of treatments used in hospitalized patients for COVID-19: a time series multicentre study. Antibiotics. 2023;12(5):809. DOI: 10.3390/antibiotics12050809
dc.identifier.doi http://dx.doi.org/10.3390/antibiotics12050809
dc.identifier.issn 2079-6382
dc.identifier.uri http://hdl.handle.net/10230/57824
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Antibiotics. 2023;12(5):809
dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword COVID-19 treatments
dc.subject.keyword SARS-CoV-2
dc.subject.keyword Antibiotics
dc.subject.keyword Antiviral drugs
dc.subject.keyword Immunomodulatory drugs
dc.subject.keyword Treatment trends
dc.title Changing trends in the global consumption of treatments used in hospitalized patients for COVID-19: a time series multicentre study
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Hospital del Mar Research Institute)