Cutibacterium spp. infections after instrumented spine surgery have a good prognosis regardless of rifampin use: a cross-sectional study

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  • dc.contributor.author Núñez-Pereira, Susana
  • dc.contributor.author Benavent, Eva
  • dc.contributor.author Ulldemolins, Marta
  • dc.contributor.author Sobrino-Díaz, Beatriz
  • dc.contributor.author Iribarren, José Antonio
  • dc.contributor.author Escudero-Sánchez, Rosa
  • dc.contributor.author Toro, María Dolores del
  • dc.contributor.author Nodar, Andrés
  • dc.contributor.author Sorli Redó, M. Luisa
  • dc.contributor.author Bahamonde, Alberto
  • dc.contributor.author Vilchez, Helem H.
  • dc.contributor.author Gasch, Oriol
  • dc.contributor.author Muñez, Elena
  • dc.contributor.author Rodríguez-Montserrat, David
  • dc.contributor.author García-País, María José
  • dc.contributor.author Haddad, Sleiman
  • dc.contributor.author Sellarès-Nadal, Julia
  • dc.contributor.author Murillo, Oscar
  • dc.contributor.author Rodríguez-Pardo, Dolors
  • dc.contributor.author GEIO–SEIMC
  • dc.date.accessioned 2023-09-06T06:36:25Z
  • dc.date.available 2023-09-06T06:36:25Z
  • dc.date.issued 2023
  • dc.description.abstract Infection after spinal instrumentation (IASI) by Cutibacterium spp. is being more frequently reported. The aim of this study was to analyse the incidence, risk factors, clinical characteristics, and outcome of a Cutibacterium spp. IASI (CG) compared with non-Cutibacterium IASI (NCG) infections, with an additional focus on the role of rifampin in the treatment. All patients from a multicentre, retrospective, observational study with a confirmed IASI between January 2010 and December 2016 were divided into two groups: (CG and NCG) IASI. Baseline, medical, surgical, infection treatment, and follow-up data were compared for both groups. In total, 411 patients were included: 27 CG and 384 NCG. The CG patients were significantly younger. They had a longer median time to diagnosis (23 vs. 13 days) (p = 0.025), although 55.6% debuted within the first month after surgery. Cutibacterium patients were more likely to have the implant removed (29.6% vs. 12.8%; p = 0.014) and received shorter antibiotic regimens (p = 0.014). In 33% of Cutibacterium cases, rifampin was added to the baseline therapy. None of the 27 infections resulted in treatment failure during follow-up regardless of rifampin use. Cutibacterium spp. is associated with a younger age and may cause both early and late IASIs. In our experience, the use of rifampin to improve the outcome in the treatment of a Cutibacterium spp. IASI is not relevant since, in our series, none of the cases had therapeutic failure regardless of the use of rifampin.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Núñez-Pereira S, Benavent E, Ulldemolins M, Sobrino-Díaz B, Iribarren JA, Escudero-Sánchez R, Del Toro MD, Nodar A, Sorli L, Bahamonde A, Vilchez HH, Gasch O, Muñez E, Rodríguez-Montserrat D, García-País MJ, Haddad S, Sellarès-Nadal J, Murillo O, Rodríguez-Pardo D, GEIO–SEIMC. Cutibacterium spp. infections after instrumented spine surgery have a good prognosis regardless of rifampin use: a cross-sectional study. Antibiotics. 2023;12(3):518. DOI: 10.3390/antibiotics12030518
  • dc.identifier.doi http://dx.doi.org/10.3390/antibiotics12030518
  • dc.identifier.issn 2079-6382
  • dc.identifier.uri http://hdl.handle.net/10230/57822
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.ispartof Antibiotics. 2023;12(3):518
  • dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Cutibacterium spp.
  • dc.subject.keyword Rifampin
  • dc.subject.keyword Spine surgery
  • dc.subject.keyword Surgical site infection
  • dc.title Cutibacterium spp. infections after instrumented spine surgery have a good prognosis regardless of rifampin use: a cross-sectional study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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