Citizen-science reveals changes in the oral microbiome in Spain through age and lifestyle factors

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  • dc.contributor.author Willis, Jesse R.
  • dc.contributor.author Saus Martínez, Ester
  • dc.contributor.author Iraola Guzmán, Susana
  • dc.contributor.author Ksiezopolska, Ewa
  • dc.contributor.author Cozzuto, Luca
  • dc.contributor.author Bejanaro, Luis A.
  • dc.contributor.author Andreu Somavilla, Núria
  • dc.contributor.author Alloza-Trabado, Miriam
  • dc.contributor.author Blanco, Andrea
  • dc.contributor.author Puig-Sola, Anna
  • dc.contributor.author Broglio, Elisabetta
  • dc.contributor.author Carolis, Carlo
  • dc.contributor.author Ponomarenko, Julia
  • dc.contributor.author Hecht, Jochen
  • dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
  • dc.date.accessioned 2022-06-21T09:18:11Z
  • dc.date.available 2022-06-21T09:18:11Z
  • dc.date.issued 2022
  • dc.description.abstract The relevance of the human oral microbiome to our understanding of human health has grown in recent years as microbiome studies continue to develop. Given the links of the oral cavity with the digestive, respiratory and circulatory systems, the composition of the oral microbiome is relevant beyond just oral health, impacting systemic processes across the body. However, we still have a very limited understanding about intrinsic and extrinsic factors that shape the composition of the healthy oral microbiome. Here, we followed a citizen-science approach to assess the relative impact on the oral microbiome of selected biological, social, and lifestyle factors in 1648 Spanish individuals. We found that the oral microbiome changes across age, with middle ages showing a more homogeneous composition, and older ages showing more diverse microbiomes with increased representation of typically low abundance taxa. By measuring differences within and between groups of individuals sharing a given parameter, we were able to assess the relative impact of different factors in driving specific microbial compositions. Chronic health disorders present in the analyzed population were the most impactful factors, followed by smoking and the presence of yeasts in the oral cavity. Finally, we corroborate findings in the literature that relatives tend to have more similar oral microbiomes, and show for the first time a similar effect for classmates. Multiple intrinsic and extrinsic factors jointly shape the oral microbiome. Comparative analysis of metabarcoding data from a large sample set allows us to disentangle the individual effects.
  • dc.description.sponsorship The authors acknowledge the Spanish Ministry for Economy, Industry and Competitiveness (MEIC) for the EMBL partnership, and Centro de Excelencia Severo Ochoa. The project was financed by the CRG through Genomics and Bioinformatics Core Facilities funds, and by the EduCaixa program through funds from the Fundación Bancaria “La Caixa”, with the participation of the Center for Research into Environmental Epidemiology (CREAL), and the “Centre d’Excellència Severo Ochoa 2013–2017” program (SEV-2012-02-08) of the Ministry of Economy and Competitiveness. TG group acknowledges support from the Spanish Ministry of Science and Innovation for grant PGC2018-099921-B-I00, cofounded by European Regional Development Fund (ERDF); from the CERCA Program / Generalitat de Catalunya; from the Catalan Research Agency (AGAUR) SGR423; from the European Union’s Horizon 2020 research and innovation program under the grant agreement ERC-2016-724173; from Instituto de Salud Carlos III (INB Grant PT17/0009/0023 - ISCIII-SGEFI/ERDF)
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Willis JR, Saus E, Iraola-Guzmán S, Ksiezopolska E, Cozzuto L, Bejarano LA et al. Citizen-science reveals changes in the oral microbiome in Spain through age and lifestyle factors. NPJ Biofilms Microbiomes. 2022 May 19;8(1):38. DOI:10.1038/s41522-022-00279-y
  • dc.identifier.doi http://dx.doi.org/10.1038/s41522-022-00279-y
  • dc.identifier.issn 2055-5008
  • dc.identifier.uri http://hdl.handle.net/10230/53554
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/724173
  • dc.rights © Jesse R. Willis et al. 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Boca -- Microbiologia
  • dc.subject.other Microbiologia
  • dc.subject.other Salut
  • dc.subject.other Malalties cròniques
  • dc.title Citizen-science reveals changes in the oral microbiome in Spain through age and lifestyle factors
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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