Early hypertransaminasemia after kidney transplantation: significance and evolution according to donor type

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• dc.contributor.author Solà Porta, Eulàlia
• dc.contributor.author Redondo Pachón, María Dolores
• dc.contributor.author Arias Cabrales, Carlos Enrique
• dc.contributor.author Navazo, Diego
• dc.contributor.author Buxeda, Anna
• dc.contributor.author Burballa Tàrrega, Carla, 1988-
• dc.contributor.author Crespo Barrio, Marta
• dc.contributor.author García-Retortillo, Montserrat
• dc.contributor.author Pascual Santos, Julio
• dc.contributor.author Pérez-Sáez, María José
• dc.date.accessioned 2022-11-15T08:29:37Z
• dc.date.available 2022-11-15T08:29:37Z
• dc.date.issued 2021
• dc.description.abstract Early hypertransaminasemia after kidney transplantation (KT) is frequent. It has been associated with the crosstalk produced between the liver and the kidney in ischemia-reperfusion situations. However, the influence of the donor type has not been evaluated. We present a retrospective study analyzing the increase in serum aspartate aminotransferase/alanine aminotransferase (AST/ALT) during the first three months post-KT in 151 recipients who received thymoglobulin as induction therapy, either from brain-death donors (DBD, n = 75), controlled circulatory death donors (cDCD, n = 33), or uncontrolled DCD (uDCD, n = 43). Eighty-five KT recipients from DBD who received basiliximab were included as controls. From KT recipients who received thymoglobulin, 33.6/43.4% presented with an increase in AST/ALT at 72 h post-KT, respectively. Regarding donor type, the percentage of recipients who experienced 72 h post-KT hypertransaminasemia was higher in uDCD group (65.1/83.7% vs. 20.3/26% in DBD and 20.7/27.6% in cDCD, p < 0.001). Within the control group, 9.4/12.9% of patients presented with AST/ALT elevation. One month after transplant, AST/ALT values returned to baseline in all groups. The multivariate analysis showed that uDCD recipients had 6- to 12-fold higher risk of developing early post-KT hypertransaminasemia. Early post-KT hypertransaminasemia is a frequent and transient event related to the kidney donor type, being more frequent in uDCD recipients.
• dc.format.mimetype application/pdf
• dc.identifier.citation Solà-Porta E, Redondo-Pachón D, Arias-Cabrales C, Navazo D, Buxeda A, Burballa C, et al. Early hypertransaminasemia after kidney transplantation: significance and evolution according to donor type. J Clin Med. 2021 Nov 4; 10(21): 5168. DOI: 10.3390/jcm10215168
• dc.identifier.doi http://dx.doi.org/10.3390/jcm10215168
• dc.identifier.issn 2077-0383
• dc.identifier.uri http://hdl.handle.net/10230/54850
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights Copyright © 2021 by Solà-Porta E, Redondo-Pachón D, Arias-Cabrales C, Navazo D, Buxeda A, Burballa C, et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Donor after circulatory death
• dc.subject.keyword Early
• dc.subject.keyword Hypertransaminasemia
• dc.subject.keyword Kidney transplantation
• dc.subject.keyword Transaminases
• dc.title Early hypertransaminasemia after kidney transplantation: significance and evolution according to donor type
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion