Proteomics characterisation of central nervous system metastasis biomarkers in triple negative breast cancer

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• dc.contributor.author Rojas Laimito, Katerin
• dc.contributor.author Trilla Fuertes, Lucía
• dc.contributor.author Gámez Pozo, Angelo
• dc.contributor.author Chiva, Cristina
• dc.contributor.author Sepúlveda, Juan M.
• dc.contributor.author Manso, Luis
• dc.contributor.author Prado Vázquez, Guillermo
• dc.contributor.author Zapater-Moros, Andrea
• dc.contributor.author López Vacas, Rocío
• dc.contributor.author Ferrer-Gómez, María
• dc.contributor.author Mendiola, César
• dc.contributor.author Espinosa Arranz, Enrique
• dc.contributor.author Sabidó Aguadé, Eduard, 1981-
• dc.contributor.author Ciruelos, Eva
• dc.contributor.author Fresno Vara, Juan Ángel
• dc.date.accessioned 2019-03-05T08:13:11Z
• dc.date.available 2019-03-05T08:13:11Z
• dc.date.issued 2019
• dc.description.abstract Background: Breast cancer (BC) is the most frequent tumour in women. Triple negative tumours (TNBC)–which are associated with minor survival rates—lack markers predictive of response to anticancer drugs. Triple negative tumours frequently metastasise to the central nervous system (CNS). Objective: The main objective of this study was to study differences in tumour protein expression between patients with CNS metastases and those without this kind of spread, and propose new biomarkers. Methods: A retrospective study was performed. Targeted proteomics and statistical analyses were used to identify possible biomarkers. Results: Proteins were quantified by a targeted proteomics approach and protein expression data were successfully obtained from 51 triple negative formalin-fixed paraffin-embedded samples. ISG15, THBS1 and AP1M1 were identified as possible biomarkers related with CNS metastasis development. Conclusions: Three possible biomarkers associated with CNS metastases in TNBC tumours were identified: ISG15, THBS1 and AP1M1. They may become markers predicting the appearance of CNS infiltration in triple negative BC.
• dc.description.sponsorship This study was funded by Instituto de Salud Carlos III, Spanish Economy and Competitiveness Ministry, Spain and by the FEDER programme, ‘Una forma de hacer Europa’ (PI12/01016, PI12/00444 and PI15/01310). LT-F is supported by the Spanish Economy and Competitiveness Ministry (DI-15-07614). GP-V is supported by Consejería de Educación, Juventud y Deporte of Comunidad de Madrid (IND2017/BMD7783). The Centre of Genomics Regulation/Universitat Pompeu Fabra Proteomics Unit is part of the ‘Plataforma de Recursos Biomoleculares y Bioinformáticos (ProteoRed)’ supported by a grant of Instituto de Salud Carlos III and Spanish Ministry of Economy and Competitiveness (PT13/0001). We acknowledge the support of the Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013–2017’ (SEV-2012-0208) and from ‘Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya’ (2014SGR678).
• dc.format.mimetype application/pdf
• dc.identifier.citation Rojas LK, Trilla-Fuertes L, Gámez-Pozo A, Chiva C, Sepúlveda J, Manso L et al. Proteomics characterisation of central nervous system metastasis biomarkers in triple negative breast cancer. Ecancermedicalscience. 2019;13:891. DOI: 10.3332/ecancer.2019.891
• dc.identifier.doi http://dx.doi.org/10.3332/ecancer.2019.891
• dc.identifier.issn 1754-6605
• dc.identifier.uri http://hdl.handle.net/10230/36728
• dc.language.iso eng
• dc.publisher Cancer Intelligence
• dc.relation.ispartof Ecancermedicalscience. 2019;13:891
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SEV-2012-0208
• dc.rights © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/3.0
• dc.subject.keyword Breast cancer
• dc.subject.keyword Triple negative
• dc.subject.keyword Proteomics
• dc.subject.keyword Central nervous system metastases
• dc.subject.keyword Biomarkers
• dc.subject.keyword Personalised medicine
• dc.title Proteomics characterisation of central nervous system metastasis biomarkers in triple negative breast cancer
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion