Acquired mechanisms of resistance to osimertinib-the next challenge
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Ríos-Hoyo, Alejandro
- dc.contributor.author Moliner Jiménez, Laura
- dc.contributor.author Arriola Aperribay, Edurne
- dc.date.accessioned 2022-10-14T06:53:19Z
- dc.date.available 2022-10-14T06:53:19Z
- dc.date.issued 2022
- dc.description.abstract EGFR-mutated tumors represent a significant percentage of non-small cell lung cancer. Despite the increasing use of osimertinib, a treatment that has demonstrated an outstanding clinical benefit with a tolerable toxicity profile, EGFR tumors eventually acquire mechanisms of resistance. In the last years, multiple mechanisms of resistance have been identified; however, after progressing on osimertinib, treatment options remain bleak. In this review, we cover the most frequent alterations and potential therapeutic strategies to overcome them.
- dc.format.mimetype application/pdf
- dc.identifier.citation Ríos-Hoyo A, Moliner L, Arriola E. Acquired mechanisms of resistance to osimertinib-the next challenge. Cancers (Basel). 2022 Apr 12; 14(8): 1931. DOI: 10.3390/cancers14081931
- dc.identifier.doi http://dx.doi.org/10.3390/cancers14081931
- dc.identifier.issn 2072-6694
- dc.identifier.uri http://hdl.handle.net/10230/54397
- dc.language.iso eng
- dc.publisher MDPI
- dc.rights Copyright © 2022 by Ríos-Hoyo A, Moliner L, Arriola E. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword EGFR
- dc.subject.keyword NSCLC
- dc.subject.keyword Mechanisms of resistance
- dc.subject.keyword Osimertinib
- dc.title Acquired mechanisms of resistance to osimertinib-the next challenge
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion