Ambient air pollution and risk of congenital anomalies: a systematic review and meta-analysis

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  • dc.contributor.author Vrijheid, Martine
  • dc.contributor.author Martinez Murciano, David
  • dc.contributor.author Manzanares-Laya, Sandra
  • dc.contributor.author Dadvand, Payam
  • dc.contributor.author Schembari, Anna, 1982-
  • dc.contributor.author Rankin, Judith
  • dc.contributor.author Nieuwenhuijsen, Mark J.
  • dc.date.accessioned 2019-07-10T07:23:43Z
  • dc.date.available 2019-07-10T07:23:43Z
  • dc.date.issued 2011
  • dc.description.abstract OBJECTIVE: We systematically reviewed epidemiologic studies on ambient air pollution and congenital anomalies and conducted meta-analyses for a number of air pollutant-anomaly combinations. DATA SOURCES AND EXTRACTION: From bibliographic searches we extracted 10 original epidemiologic studies that examined the association between congenital anomaly risk and concentrations of air pollutants. Meta-analyses were conducted if at least four studies published risk estimates for the same pollutant and anomaly group. Summary risk estimates were calculated for a) risk at high versus low exposure level in each study and b) risk per unit increase in continuous pollutant concentration. DATA SYNTHESIS: Each individual study reported statistically significantly increased risks for some combinations of air pollutants and congenital anomalies, among many combinations tested. In meta-analyses, nitrogen dioxide (NO₂) and sulfur dioxide (SO₂) exposures were related to increases in risk of coarctation of the aorta [odds ratio (OR) per 10 ppb NO₂ = 1.17; 95% confidence interval (CI), 1.00-1.36; OR per 1 ppb SO₂ = 1.07; 95% CI, 1.01-1.13] and tetralogy of Fallot (OR per 10 ppb NO₂ = 1.20; 95% CI, 1.02-1.42; OR per 1 ppb SO₂ = 1.03; 95% CI, 1.01-1.05), and PM₁₀ (particulate matter ≤ 10 µm) exposure was related to an increased risk of atrial septal defects (OR per 10 μg/m³ = 1.14; 95% CI, 1.01-1.28). Meta-analyses found no statistically significant increase in risk of other cardiac anomalies and oral clefts. CONCLUSIONS: We found some evidence for an effect of ambient air pollutants on congenital cardiac anomaly risk. Improvements in the areas of exposure assessment, outcome harmonization, assessment of other congenital anomalies, and mechanistic knowledge are needed to advance this field.
  • dc.description.sponsorship J.R. is funded by a Personal Award Scheme Career Scientist Award from the U.K. National Institute of Health Research
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Vrijheid M, Martinez D, Manzanares S, Dadvand P, Schembari A, Rankin J et al. Ambient air pollution and risk of congenital anomalies: a systematic review and meta-analysis. Environ Health Perspect. 2011 May;119(5):598-606. DOI: 10.1289/ehp.1002946
  • dc.identifier.doi http://dx.doi.org/10.1289/ehp.1002946
  • dc.identifier.issn 1552-9924
  • dc.identifier.uri http://hdl.handle.net/10230/41972
  • dc.language.iso eng
  • dc.publisher National Institute of Environmental Health Sciences (NIEHS)
  • dc.relation.ispartof Environmental Health Perspectives. 2011 May;119(5):598-606
  • dc.rights Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, "Reproduced with permission from Environmental Health Perspectives"); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.other Aire -- Contaminació
  • dc.subject.other Malformacions
  • dc.subject.other Embaràs
  • dc.title Ambient air pollution and risk of congenital anomalies: a systematic review and meta-analysis
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

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