How cancer exploits ribosomal RNA biogenesis: A journey beyond the boundaries of rRNA transcription
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- dc.contributor.author Gaviraghi, Marco
- dc.contributor.author Vivori, Claudia, 1989-
- dc.contributor.author Tonon, Giovanni
- dc.date.accessioned 2020-04-14T07:15:23Z
- dc.date.available 2020-04-14T07:15:23Z
- dc.date.issued 2019
- dc.description.abstract The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit various mechanisms to boost ribosome biogenesis. In this review, we will summarize how oncogenes and tumor suppressors modulate the biosynthesis of the RNA component of ribosomes, starting from the description of well-characterized pathways that converge on ribosomal RNA transcription while including novel insights that reveal unexpected regulatory networks hacked by cancer cells to unleash ribosome production.
- dc.format.mimetype application/pdf
- dc.identifier.citation Gaviraghi M, Vivori C, Tonon G. How cancer exploits ribosomal RNA biogenesis: A journey beyond the boundaries of rRNA transcription. Cells. 2019; 8(9). pii: E1098. DOI: 10.3390/cells8091098
- dc.identifier.doi http://dx.doi.org/10.3390/cells8091098
- dc.identifier.issn 2073-4409
- dc.identifier.uri http://hdl.handle.net/10230/44205
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Cells. 2019; 8(9). pii: E1098
- dc.rights © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cancer
- dc.subject.keyword Decapping
- dc.subject.keyword Oncogenes
- dc.subject.keyword Ribosomal RNA (rRNA)
- dc.subject.keyword Ribosomes
- dc.subject.keyword Small nucleolar RNAs (snoRNA)
- dc.title How cancer exploits ribosomal RNA biogenesis: A journey beyond the boundaries of rRNA transcription
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion