COPD: systemic proteomic profiles in frequent and infrequent exacerbators

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  • dc.contributor.author Enríquez Rodríguez, César Jessé
  • dc.contributor.author Casadevall Fusté, Carme
  • dc.contributor.author Faner, Rosa
  • dc.contributor.author Castro Costa, Ady
  • dc.contributor.author Pascual Guàrdia, Sergi, 1979-
  • dc.contributor.author Seijó Maceiras, Luis
  • dc.contributor.author López Campos, José Luis
  • dc.contributor.author Peces-Barba Romero, Germán
  • dc.contributor.author Monsó Molas, Eduard
  • dc.contributor.author Barreiro Portela, Esther
  • dc.contributor.author Cosío, Borja G.
  • dc.contributor.author Agustí García-Navarro, Àlvar
  • dc.contributor.author Gea Guiral, Joaquim
  • dc.contributor.author BIOMEPOC group
  • dc.date.accessioned 2024-06-05T06:15:49Z
  • dc.date.available 2024-06-05T06:15:49Z
  • dc.date.issued 2024
  • dc.description Data de publicació electrònica: 25-03-2024
  • dc.description.abstract Background: Some patients with COPD suffer frequent exacerbations (FE). We hypothesised that their systemic proteomic profile would be different from that of non-frequent exacerbators (NFE). The objective of the present study was to contrast the systemic proteomic profile in FE versus NFE. As a reference, we also determined the systemic proteomic profile of healthy controls (HC) and COPD patients during an actual episode of exacerbation (AE). Methods: In the analysis we included 40 clinically stable COPD patients (20 FE and 20 NFE), and 20 HC and 10 AE patients. Their plasma samples were analysed by combining two complementary proteomic approaches: label-free liquid chromatography-tandem mass spectrometry and multiplex immunoassays. Gene Ontology annotation, pathway enrichment and network analyses were used to investigate molecular pathways associated with differentially abundant proteins/peptides (DAPs). Results: Compared with HC, we identified 40 DAPs in FE, 10 in NFE and 63 in AE. Also compared to HC, pathway functional and protein-protein network analyses revealed dysregulation of inflammatory responses involving innate and antibody-mediated immunity in COPD, particularly in the FE group, as well as during an AE episode. Besides, we only identified alterations in the complement and coagulation cascades in AE. Conclusion: There are specific plasma proteome profiles associated with FE, which are partially shared with findings observed during AE, albeit others are uniquely present during the actual episode of AE.
  • dc.description.sponsorship Support statement: Funded by project SAF2014-54371 from the Spanish Ministerio de Economía y Competitividad and co-funded by the European Union, project PI21/00785 from Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union, SEPAR 2015, 2016 and 2019, FUCAP 2014, SOCAP 2020, and Menarini (unrestricted Grant 2015-19). C.J. Enríquez-Rodríguez is a recipient of a Predoctoral Grant PFIS from ISCIII and co-funded by the European Union (ref. FI22/00003). Funding information for this article has been deposited with the Crossref Funder Registry.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Enríquez-Rodríguez CJ, Casadevall C, Faner R, Castro-Costa A, Pascual-Guàrdia S, Seijó L, et al. COPD: systemic proteomic profiles in frequent and infrequent exacerbators. ERJ Open Res. 2024 Mar 25;10(2):00004-2024. DOI: 10.1183/23120541.00004-2024
  • dc.identifier.doi http://dx.doi.org/10.1183/23120541.00004-2024
  • dc.identifier.issn 2312-0541
  • dc.identifier.uri http://hdl.handle.net/10230/60352
  • dc.language.iso eng
  • dc.publisher European Respiratory Society
  • dc.relation.ispartof ERJ Open Res. 2024 Mar 25;10(2):00004-2024
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2014-54371
  • dc.rights © The authors 2024. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0 (http://creativecommons.org/licenses/by-nc/4.0/). For commercial reproduction rights and permissions contact permissions@ersnet.org
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.subject.other Pulmons--Malalties obstructives
  • dc.title COPD: systemic proteomic profiles in frequent and infrequent exacerbators
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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