Clonal dynamics monitoring during clinical evolution in chronic lymphocytic leukaemia

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• dc.contributor.author González-Rincón, Julia
• dc.contributor.author Gómez, Sagrario
• dc.contributor.author Martinez, Nerea
• dc.contributor.author Troulé, Kevin
• dc.contributor.author Perales-Patón, Javier
• dc.contributor.author Derdak, Sophia
• dc.contributor.author Beltran, Sergi
• dc.contributor.author Fernández-Cuevas, Belén
• dc.contributor.author Pérez-Sanz, Nuria
• dc.contributor.author Nova-Gurumeta, Sara
• dc.contributor.author Gut, Ivo Glynne
• dc.contributor.author Al-Shahrour, Fátima
• dc.contributor.author Piris, Miguel A.
• dc.contributor.author García-Marco, J. A.
• dc.contributor.author Sánchez-Beato, Margarita
• dc.date.accessioned 2019-03-18T08:38:11Z
• dc.date.available 2019-03-18T08:38:11Z
• dc.date.issued 2019
• dc.description.abstract Chronic lymphocytic leukaemia is the most prevalent leukaemia in Western countries. It is an incurable disease characterized by a highly variable clinical course. Chronic lymphocytic leukaemia is an ideal model for studying clonal heterogeneity and dynamics during cancer progression, response to therapy and/or relapse because the disease usually develops over several years. Here we report an analysis by deep sequencing of sequential samples taken at different times from the affected organs of two patients with 12- and 7-year disease courses, respectively. One of the patients followed a linear pattern of clonal evolution, acquiring and selecting new mutations in response to salvage therapy and/or allogeneic transplantation, while the other suffered loss of cellular tumoral clones during progression and histological transformation.
• dc.description.sponsorship This work was supported by the Spanish Ministry of Economy and Competence (MINECO): SAF2013-47416-R; ISCIII-MINECO AES-FEDER (Plan Estatal de I + D + I 2008–2011 and 2013–2016) (PI14/00221 (MSB), PIE14/0064 (MSB), PIE15/0081 (MAP), PI16/01294 (MAP), CIBERONC CB16/12/00291 (MAP)), Madrid Autonomous Community, B2017/BMD3778 (MAP, MSB, FA-S), F Hoffmann-La Roche (JAGM); CNIO Bioinformatics Unit work has been supported by Marie-Curie Career Integration Grant CIG334361. J.G.-R. is a recipient of a i-PFIS predoctoral fellowship (IFI14/00003); NM was supported by AECC Scientific Foundation; S.D. was supported by the Torres Quevedo subprogramme (MICINN) under grant agreement PTQ-12-05391. K.T. and J.P.-P. are supported by Severo Ochoa FPI grant doctoral fellowship by the Spanish MINECO. MSB currently holds a Miguel Servet II contract (CPII16/00024) supported by ISCIII-MINECO AES-FEDER (Plan Estatal I + D + I 2013–2016) and the Fundación de Investigación Biomédica Puerta de Hierro.
• dc.format.mimetype application/pdf
• dc.identifier.citation González-Rincón J, Gómez S, Martinez N, Troulé K, Perales-Patón J, Derdak S et al. Clonal dynamics monitoring during clinical evolution in chronic lymphocytic leukaemia. Sci Rep. 2019;9(1):975. DOI: 10.1038/s41598-018-37389-7
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-018-37389-7
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/36851
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Scientific Reports. 2019;9(1):975
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-47416-R
• dc.rights © The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cancer genetics
• dc.subject.keyword Molecular medicine
• dc.title Clonal dynamics monitoring during clinical evolution in chronic lymphocytic leukaemia
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion