Prognostic value of the acute-to-chronic glycemic ratio at admission in heart failure: a prospective study
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Carrera Santaliestra, M. José
- dc.contributor.author Moliner Borja, Pedro
- dc.contributor.author Llauradó Cabot, Gemma
- dc.contributor.author Enjuanes Grau, Cristina
- dc.contributor.author Conangla, Laura
- dc.contributor.author Chillarón Jordan, Juan José
- dc.contributor.author Ballesta, Silvia
- dc.contributor.author Climent Biescas, Elisenda
- dc.contributor.author Comín Colet, Josep
- dc.contributor.author Flores-Le-Roux, Juana Antonia
- dc.date.accessioned 2022-10-03T05:39:18Z
- dc.date.available 2022-10-03T05:39:18Z
- dc.date.issued 2021
- dc.description.abstract Acute hyperglycemia has been associated with worse prognosis in patients hospitalized for heart failure (HF). Nevertheless, studies evaluating the impact of glycemic control on long-term prognosis have shown conflicting results. Our aim was to assess the relationship between acute-to-chronic (A/C) glycemic ratio and 4-year mortality in a cohort of subjects hospitalized for acute HF. A total of 1062 subjects were consecutively included. We measured glycaemia at admission and estimated average chronic glucose levels and the A/C glycemic ratio were calculated. Subjects were stratified into groups according to the A/C glycemic ratio tertiles. The primary endpoint was 4-year mortality. Subjects with diabetes had higher risk for mortality compared to those without (HR 1.35 [95% CI: 1.10-1.65]; p = 0.004). A U-shape curve association was found between glucose at admission and mortality, with a HR of 1.60 [95% CI: 1.22-2.11]; p = 0.001, and a HR of 1.29 [95% CI: 0.97-1.70]; p = 0.078 for the first and the third tertile, respectively, in subjects with diabetes. Additionally, the A/C glycemic ratio was negatively associated with mortality (HR 0.76 [95% CI: 0.58-0.99]; p = 0.046 and HR 0.68 [95% CI: 0.52-0.89]; p = 0.005 for the second and third tertile, respectively). In multivariable analysis, the A/C glycemic ratio remained an independent predictor. In conclusion, in subjects hospitalized for acute HF, the A/C glycemic ratio is significantly associated with mortality, improving the ability to predict mortality compared with glucose levels at admission or average chronic glucose concentrations, especially in subjects with diabetes.
- dc.format.mimetype application/pdf
- dc.identifier.citation Carrera MJ, Moliner P, Llauradó G, Enjuanes C, Conangla L, Chillarón JJ, Ballesta S, Climent E, Comín-Colet J, Flores-Le Roux JA. Prognostic value of the acute-to-chronic glycemic ratio at admission in heart failure: a prospective study. J Clin Med. 2021 Dec 21;11(1):6. DOI: 10.3390/jcm11010006
- dc.identifier.doi http://dx.doi.org/10.3390/jcm11010006
- dc.identifier.issn 2077-0383
- dc.identifier.uri http://hdl.handle.net/10230/54235
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof J Clin Med. 2021 Dec 21;11(1):6
- dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Chronic complications
- dc.subject.keyword Diabetes mellitus
- dc.subject.keyword Heart failure
- dc.title Prognostic value of the acute-to-chronic glycemic ratio at admission in heart failure: a prospective study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion