Mid-childhood fat mass and airflow limitation at 15 years: The mediating role of insulin resistance and C-reactive protein

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Peralta, Gabriela P.
• dc.contributor.author Granell, Raquel
• dc.contributor.author Bédard, Annabelle, 1986-
• dc.contributor.author Carsin, Anne-Elie
• dc.contributor.author Fuertes, Elaine
• dc.contributor.author Howe, Laura D.
• dc.contributor.author Márquez, Sandra
• dc.contributor.author Jarvis, Deborah
• dc.contributor.author García Aymerich, Judith
• dc.date.accessioned 2023-03-03T07:40:15Z
• dc.date.available 2023-03-03T07:40:15Z
• dc.date.issued 2022
• dc.description.abstract Background: We previously reported an association of high fat mass levels from age 9 to 15 years with lower forced expiratory flow in 1 s (FEV1 )/forced vital capacity (FVC) ratio (i.e., increased risk of airflow limitation) at 15 years. Here, we aimed to assess whether insulin resistance and C-reactive protein (CRP) at 15 years partially mediate this association. Methods: We included 2263 children from the UK Avon Longitudinal Study of Parents and Children population-based cohort (ALSPAC). Four fat mass index (FMI) trajectories ("low," "medium-low," "medium-high," "high") from 9 to 15 years were previously identified using Group-Based Trajectory Modeling. Data on CRP, glucose, insulin, and post-bronchodilator FEV1 /FVC were available at 15 years. We defined insulin resistance by the homeostasis model assessment-estimated insulin resistance index (HOMA-IR). We used adjusted linear regression models and a causal mediation analysis to assess the mediating role of HOMA-IR and CRP. Results: Compared to children in the "low" FMI trajectory, children in the "medium-high" and "high" FMI trajectories had lower FEV1 /FVC at 15 years. The percentage of the total effect explained by HOMA-IR was 19.8% [-114.1 to 170.0] and 20.4% [1.6 to 69.0] for the "medium-high" and "high" trajectories, respectively. In contrast, there was little evidence for a mediating role of CRP. Conclusion: The association between mid-childhood fat mass and FEV1 /FVC ratio at 15 years may be partially mediated by insulin resistance.
• dc.description.sponsorship The present analyses are part of the Aging Lungs in European Cohorts (ALEC) Study (www.alecstudy.org), which has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No. 633212.
• dc.format.mimetype application/pdf
• dc.identifier.citation Peralta GP, Granell R, Bédard A, Carsin AE, Fuertes E, Howe LD, Márquez S, Jarvis DL, Garcia-Aymerich J. Mid-childhood fat mass and airflow limitation at 15 years: The mediating role of insulin resistance and C-reactive protein. Pediatr Allergy Immunol. 2022 Dec;33(12):e13894. DOI: 10.1111/pai.13894
• dc.identifier.doi http://dx.doi.org/10.1111/pai.13894
• dc.identifier.issn 0905-6157
• dc.identifier.uri http://hdl.handle.net/10230/56015
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Pediatr Allergy Immunol. 2022 Dec;33(12):e13894
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/633212
• dc.rights © 2022 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword ALSPAC
• dc.subject.keyword C-reactive protein
• dc.subject.keyword Airflow limitation
• dc.subject.keyword Epidemiology
• dc.subject.keyword Insulin resistance
• dc.subject.keyword Mediation
• dc.subject.keyword Obesity
• dc.title Mid-childhood fat mass and airflow limitation at 15 years: The mediating role of insulin resistance and C-reactive protein
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion