In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth

Zhang, Shaoshi; Deco, Gustavo; Yeo, B. T. Thomas

doi:http://dx.doi.org/10.1073/pnas.2318641121

In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth

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Zhang S, Larsen B, Sydnor VJ, et al. In vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth. Proc Natl Acad Sci U S A. 2024;121(23):e2318641121. DOI: 10.1073/pnas.2318641121

Abstract

A balanced excitation-inhibition ratio (E/I ratio) is critical for healthy brain function. Normative development of cortex-wide E/I ratio remains unknown. Here, we noninvasively estimate a putative marker of whole-cortex E/I ratio by fitting a large-scale biophysically plausible circuit model to resting-state functional MRI (fMRI) data. We first confirm that our model generates realistic brain dynamics in the Human Connectome Project. Next, we show that the estimated E/I ratio marker is sensitive to the gamma-aminobutyric acid (GABA) agonist benzodiazepine alprazolam during fMRI. Alprazolam-induced E/I changes are spatially consistent with positron emission tomography measurement of benzodiazepine receptor density. We then investigate the relationship between the E/I ratio marker and neurodevelopment. We find that the E/I ratio marker declines heterogeneously across the cerebral cortex during youth, with the greatest reduction occurring in sensorimotor systems relative to association systems. Importantly, among children with the same chronological age, a lower E/I ratio marker (especially in the association cortex) is linked to better cognitive performance. This result is replicated across North American (8.2 to 23.0 y old) and Asian (7.2 to 7.9 y old) cohorts, suggesting that a more mature E/I ratio indexes improved cognition during normative development. Overall, our findings open the door to studying how disrupted E/I trajectories may lead to cognitive dysfunction in psychopathology that emerges during youth.