Phenotyping asthma, rhinitis, and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster

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• dc.contributor.author García Aymerich, Judithca
• dc.contributor.author Benet, Martaca
• dc.contributor.author Saeys, Y.ca
• dc.contributor.author Pinart, Marionaca
• dc.contributor.author Basagaña Flores, Xavierca
• dc.contributor.author Smit, Henriëtte A.ca
• dc.contributor.author Siroux, Valérieca
• dc.contributor.author Just, Jocelyneca
• dc.contributor.author Momas, Isabelleca
• dc.contributor.author Rancière, Fannyca
• dc.contributor.author Keil, Thomasca
• dc.contributor.author Hohmann, Cynthiaca
• dc.contributor.author Lau, Susanneca
• dc.contributor.author Wahn, Ulrichca
• dc.contributor.author Heinrich, Joachimca
• dc.contributor.author Tischer, Christinaca
• dc.contributor.author Fantini, Maria Piaca
• dc.contributor.author Lenzi, Jacopoca
• dc.contributor.author Porta, Danielaca
• dc.contributor.author Koppelman, Gerard H.ca
• dc.contributor.author Postma, Dirkje S.ca
• dc.contributor.author Berdel, Dietrichca
• dc.contributor.author Koletzko, Sibylleca
• dc.contributor.author Kerkhof, Marjanca
• dc.contributor.author Gehring, Ulrikeca
• dc.contributor.author Wickman, Magnusca
• dc.contributor.author Melén, Erikca
• dc.contributor.author Hallberg, Jennyca
• dc.contributor.author Bindslev Jensen, Carstenca
• dc.contributor.author Eller, Esbenca
• dc.contributor.author Kull, Ingerca
• dc.contributor.author Lodrup Carlsen, Karin C.ca
• dc.contributor.author Carlsen, Kai-Håkonca
• dc.contributor.author Lambrecht, Bart N.ca
• dc.contributor.author Kogevinas, Manolisca
• dc.contributor.author Sunyer Deu, Jordica
• dc.contributor.author Kauffmann, Francineca
• dc.contributor.author Bousquet, Jeanca
• dc.contributor.author Antó i Boqué, Josep Mariaca
• dc.date.accessioned 2017-12-21T10:46:35Z
• dc.date.available 2017-12-21T10:46:35Z
• dc.date.issued 2015
• dc.description.abstract BACKGROUND: Asthma, rhinitis and eczema often co-occur in children, but their interrelationships at the population level have been poorly addressed. We assessed co-occurrence of childhood asthma, rhinitis and eczema using unsupervised statistical techniques. METHODS: We included 17 209 children at 4 years and 14 585 at 8 years from seven European population-based birth cohorts (MeDALL project). At each age period, children were grouped, using partitioning cluster analysis, according to the distribution of 23 variables covering symptoms 'ever' and 'in the last 12 months', doctor diagnosis, age of onset and treatments of asthma, rhinitis and eczema; immunoglobulin E sensitization; weight; and height. We tested the sensitivity of our estimates to subject and variable selections, and to different statistical approaches, including latent class analysis and self-organizing maps. RESULTS: Two groups were identified as the optimal way to cluster the data at both age periods and in all sensitivity analyses. The first (reference) group at 4 and 8 years (including 70% and 79% of children, respectively) was characterized by a low prevalence of symptoms and sensitization, whereas the second (symptomatic) group exhibited more frequent symptoms and sensitization. Ninety-nine percentage of children with comorbidities (co-occurrence of asthma, rhinitis and/or eczema) were included in the symptomatic group at both ages. The children's characteristics in both groups were consistent in all sensitivity analyses.CONCLUSION:At 4 and 8 years, at the population level, asthma, rhinitis and eczema can be classified together as an allergic comorbidity cluster. Future research including time-repeated assessments and biological data will help understanding the interrelationships between these diseases.
• dc.description.sponsorship This work was supported by Mechanisms of the Develop-ment of ALLergy (MeDALL), a collaborative project con-ducted within the European Union under the HealthCooperation Work Programme of the 7th Framework pro-gramme (grant agreement No. 261357)
• dc.format.mimetype application/pdfca
• dc.identifier.citation Garcia-Aymerich J, Benet M, Saeys Y, Pinart M, Basagaña X, Smit HA et al. Phenotyping asthma, rhinitis, and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster. Allergy. 2015 Aug;70(8):973-84. DOI: 10.1111/all.12640
• dc.identifier.doi http://dx.doi.org/10.1111/all.12640
• dc.identifier.issn 0105-4538
• dc.identifier.uri http://hdl.handle.net/10230/33555
• dc.language.iso eng
• dc.publisher Wileyca
• dc.relation.ispartof Allergy. 2015 Aug;70(8):973-84
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
• dc.rights This is the pre-peer reviewed version of the following article: Garcia-Aymerich J, Benet M, Saeys Y, Pinart M, Basagaña X, Smit HA et al. Phenotyping asthma, rhinitis, and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster. Allergy. 2015 Aug; 70(8): 973-84, which has been published in final form at http://dx.doi.org/10.1111/all.12640. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Asma
• dc.subject.other Rinitis
• dc.subject.other Èczema
• dc.subject.other Al·lèrgia
• dc.title Phenotyping asthma, rhinitis, and eczema in MeDALL population-based birth cohorts: an allergic comorbidity clusterca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion