Evolutionary genomics and conservation of the endangered Przewalski's horse

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  • dc.contributor.author Der Sarkissian, Clioca
  • dc.contributor.author Lorente-Galdós, Belén, 1981-ca
  • dc.contributor.author Marquès i Bonet, Tomàs, 1975-ca
  • dc.contributor.author Orlando, Ludovicca
  • dc.date.accessioned 2017-10-23T14:26:38Z
  • dc.date.available 2017-10-23T14:26:38Z
  • dc.date.issued 2015
  • dc.description.abstract Przewalski's horses (PHs, Equus ferus ssp. przewalskii) were discovered in the Asian steppes in the 1870s and represent the last remaining true wild horses. PHs became extinct in the wild in the 1960s but survived in captivity, thanks to major conservation efforts. The current population is still endangered, with just 2,109 individuals, one-quarter of which are in Chinese and Mongolian reintroduction reserves [1]. These horses descend from a founding population of 12 wild-caught PHs and possibly up to four domesticated individuals [2-4]. With a stocky build, an erect mane, and stripped and short legs, they are phenotypically and behaviorally distinct from domesticated horses (DHs, Equus caballus). Here, we sequenced the complete genomes of 11 PHs, representing all founding lineages, and five historical specimens dated to 1878-1929 CE, including the Holotype. These were compared to the hitherto-most-extensive genome dataset characterized for horses, comprising 21 new genomes. We found that loci showing the most genetic differentiation with DHs were enriched in genes involved in metabolism, cardiac disorders, muscle contraction, reproduction, behavior, and signaling pathways. We also show that DH and PH populations split ∼45,000 years ago and have remained connected by gene-flow thereafter. Finally, we monitor the genomic impact of ∼110 years of captivity, revealing reduced heterozygosity, increased inbreeding, and variable introgression of domestic alleles, ranging from non-detectable to as much as 31.1%. This, together with the identification of ancestry informative markers and corrections to the International Studbook, establishes a framework for evaluating the persistence of genetic variation in future reintroduced populations.
  • dc.description.sponsorship This work was supported by the Danish Council for Independent Research, Natural Sciences (FNU-4002-00152B); the Danish National Research Foundation (DNFR94); the Villum Fonden Blokstipendium (2014); the Lundbeck Foundation (R52-A5062); the Israel Science Foundation (1365/10); the German Research Council (DFG-LU852/7-4); the NIH (R01-GM40282); the Caesar Kleberg Foundation for Wildlife Conservation; the John and Beverly Stauffer Foundation; FP7 European Marie-Curie programs (CIG-293845, ITN-290344, IEF-328024, IEF-299176, and IEF-302617); a National Science Foundation Graduate Research Fellowship; and the Human Frontier Science Program (LT000320/2014).
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Der Sarkissian C, Ermini L, Schubert M, Yang MA, Librado P, Fumagalli M et al. Evolutionary genomics and conservation of the endangered Przewalski's horse. Curr Biol. 2015 Oct 5;25(19):2577-83. DOI: 10.1016/j.cub.2015.08.032
  • dc.identifier.doi http://dx.doi.org/10.1016/j.cub.2015.08.032
  • dc.identifier.issn 0960-9822
  • dc.identifier.uri http://hdl.handle.net/10230/33065
  • dc.language.iso eng
  • dc.publisher Elsevierca
  • dc.relation.ispartof Current Biology. 2015 Oct 5;25(19):2577-83
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/293845
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/290344
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/328024
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/299176
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/302617
  • dc.rights © Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.cub.2015.08.032 that appeared in the journal Current Biology. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-license
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-license
  • dc.subject.keyword Breeding
  • dc.subject.keyword Genetic Variation
  • dc.subject.keyword Genomics
  • dc.subject.keyword Horses/genetics
  • dc.subject.keyword Sequence Analysis, DNA
  • dc.title Evolutionary genomics and conservation of the endangered Przewalski's horseca
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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