Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study
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- dc.contributor.author Sousa Pinto, Bernardo
- dc.contributor.author Antó i Boqué, Josep Maria
- dc.contributor.author MASK‐air think tank
- dc.date.accessioned 2024-07-19T07:11:35Z
- dc.date.available 2024-07-19T07:11:35Z
- dc.date.issued 2024
- dc.description.abstract Rationale: It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives: To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods: In this cross-sectional study, we assessed real-world data using the MASK-air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma. Measurement and main results: We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma. Conclusions: Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.
- dc.format.mimetype application/pdf
- dc.identifier.citation Sousa-Pinto B, Louis G, Vieira RJ, Czarlewski W, Anto JM, Amaral R, et al. Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study. Clin Transl Allergy. 2024 Jun;14(6):e12358. DOI: 10.1002/clt2.12358
- dc.identifier.doi http://dx.doi.org/10.1002/clt2.12358
- dc.identifier.issn 2045-7022
- dc.identifier.uri http://hdl.handle.net/10230/60798
- dc.language.iso eng
- dc.publisher BioMed Central
- dc.relation.ispartof Clin Transl Allergy. 2024 Jun;14(6):e12358
- dc.rights © 2024 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Asthma
- dc.subject.keyword Diagnosis
- dc.subject.keyword Dyspnea
- dc.subject.keyword mHealth
- dc.subject.keyword Wheezing
- dc.title Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion