Association of microbiota polyphenols with cardiovascular health in the context of a Mediterranean diet

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  • dc.contributor.author Domínguez-López, Inés
  • dc.contributor.author Arancibia-Riveros, Camila
  • dc.contributor.author Marhuenda Muñoz, María
  • dc.contributor.author Tresserra-Rimbau, Anna
  • dc.contributor.author Toledo, Estefania
  • dc.contributor.author Fitó Colomer, Montserrat
  • dc.contributor.author Ros, Emilio
  • dc.contributor.author Estruch, Ramón
  • dc.contributor.author Lamuela-Raventós, Rosa M.
  • dc.date.accessioned 2024-04-12T06:43:30Z
  • dc.date.available 2024-04-12T06:43:30Z
  • dc.date.issued 2023
  • dc.description.abstract Background and aims The Mediterranean diet (MedDiet) is rich in polyphenols, phytochemicals that are beneficial for cardiovascular health. Phenolic compounds have poor bioavailability but they are extensively metabolized by the gut microbiota. Therefore, we aimed to assess the association of microbial phenolic metabolites (MPM) with adherence to the MedDiet, and their relationship with ideal cardiovascular health (ICVH) and cardiovascular risk factors. Methods and results This cross-sectional substudy within the PREDIMED trial included 200 participants from the Barcelona-Clinic recruitment center. Five MPM were identified and quantified using a novel method based on liquid chromatography coupled to mass spectrometry: protocatechuic acid (PCA), enterodiol glucuronide (EDG), enterolactone glucuronide (ELG), vanillic acid glucuronide (VAG) and urolithin B glucuronide (UBG). Multivariable-adjusted regressions were used to evaluate the associations between MPM and MedDiet adherence, ICVH score, biochemical parameters, and blood pressure. Additionally, an MPM score was calculated as the weighted sum of MedDiet adherence and ICVH and found to be directly associated. Among individual polyphenols, UBG was inversely associated with LDL-cholesterol. Conclusions A score of urinary MPM was associated with higher adherence to the MedDiet and ICVH, and individual MPM were related to better cardiovascular health. These findings suggest that the MedDiet may affect gut microbiota, whose metabolites are linked with cardiovascular health.
  • dc.description.sponsorship This research has been supported by the CICYT [PID2020-114022RB-I00], the NIH grant “Mediterranean diet, Metabolites, and Cardiovascular Disease” (2R01HL118264-09 and 5R01HL118264-08), CIBEROBN from the Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades, (AEI/FEDER, UE) and Generalitat de Catalunya (GC) [2017SGR 196]. INSA-UB is Maria de Maeztu Unit of Excellence (grant CEX2021-001234-M funded by MICIN/AEI/FEDER, UE). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Domínguez-López I, Arancibia-Riveros C, Marhuenda-Muñoz M, Tresserra-Rimbau A, Toledo E, Fitó M, et al. Association of microbiota polyphenols with cardiovascular health in the context of a Mediterranean diet. Food Res Int. 2023 Mar;165:112499. DOI: 10.1016/j.foodres.2023.112499
  • dc.identifier.doi http://dx.doi.org/10.1016/j.foodres.2023.112499
  • dc.identifier.issn 0963-9969
  • dc.identifier.uri http://hdl.handle.net/10230/59746
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Food Res Int. 2023 Mar;165:112499
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-114022RB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/CEX2021-001234-M
  • dc.rights © 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword PREDIMED
  • dc.subject.keyword Mediterranean diet
  • dc.subject.keyword LTQ-Orbitrap-MS
  • dc.subject.keyword Gut microbiota
  • dc.subject.keyword Polyphenols
  • dc.subject.keyword Antioxidants
  • dc.subject.keyword Postbiotics
  • dc.subject.keyword Healthy diet
  • dc.title Association of microbiota polyphenols with cardiovascular health in the context of a Mediterranean diet
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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