Genetic evidence for an origin of the Armenians from Bronze Age mixing of multiple populations

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  • dc.contributor.author Haber, Marc, 1980-ca
  • dc.contributor.author Mezzavilla, Massimoca
  • dc.contributor.author Xue, Yalica
  • dc.contributor.author Comas, David, 1969-ca
  • dc.contributor.author Gasparini, Paoloca
  • dc.contributor.author Zalloua, Pierre A.ca
  • dc.contributor.author Tyler-Smith, Chrisca
  • dc.date.accessioned 2016-01-25T18:31:32Z
  • dc.date.available 2016-01-25T18:31:32Z
  • dc.date.issued 2015
  • dc.description.abstract The Armenians are a culturally isolated population who historically inhabited a region in the Near East bounded by the Mediterranean and Black seas and the Caucasus, but remain under-represented in genetic studies and have a complex history including a major geographic displacement during World War I. Here, we analyse genome-wide variation in 173 Armenians and compare them with 78 other worldwide populations. We find that Armenians form a distinctive cluster linking the Near East, Europe, and the Caucasus. We show that Armenian diversity can be explained by several mixtures of Eurasian populations that occurred between 3000 and 2000 bce, a period characterized by major population migrations after the domestication of the horse, appearance of chariots, and the rise of advanced civilizations in the Near East. However, genetic signals of population mixture cease after 1200 bce when Bronze Age civilizations in the Eastern Mediterranean world suddenly and violently collapsed. Armenians have since remained isolated and genetic structure within the population developed 500 years ago when Armenia was divided between the Ottomans and the Safavid Empire in Iran. Finally, we show that Armenians have higher genetic affinity to Neolithic Europeans than other present-day Near Easterners, and that 29% of Armenian ancestry may originate from an ancestral population that is best represented by Neolithic Europeansca
  • dc.description.sponsorship This work was supported by Wellcome Trust grant 098051
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Haber M, Mezzavilla M, Xue Y, Comas D, Gasparini P, Zalloua P et al. Genetic evidence for an origin of the Armenians from Bronze Age mixing of multiple populations. European journal of human genetics: EJHG. 2015;24:931-6. DOI: 10.1038/ejhg.2015.206ca
  • dc.identifier.doi http://dx.doi.org/10.1038/ejhg.2015.206
  • dc.identifier.issn 1018-4813
  • dc.identifier.uri http://hdl.handle.net/10230/25648
  • dc.language.iso engca
  • dc.publisher Nature Publishing Groupca
  • dc.relation.ispartof European journal of human genetics: EJHG. 2015;24:931-6
  • dc.rights © Nature Publishing Group. http://dx.doi.org/10.1038/ejhg.2015.206. This work is licensed under a Creative Commons Attribution 4.0 International Licenseca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0ca
  • dc.subject.other Armèniaca
  • dc.subject.other Genètica de poblacions humanesca
  • dc.title Genetic evidence for an origin of the Armenians from Bronze Age mixing of multiple populationsca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca