DNA methylation: insights into human evolution

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• dc.contributor.author Hernando Herráez, Irene, 1985-ca
• dc.contributor.author García Pérez, Raquel, 1989-ca
• dc.contributor.author Sharp, Andrew J.ca
• dc.contributor.author Marquès i Bonet, Tomàs, 1975-ca
• dc.date.accessioned 2016-01-28T14:18:26Z
• dc.date.available 2016-01-28T14:18:26Z
• dc.date.issued 2015
• dc.description.abstract A fundamental initiative for evolutionary biologists is to understand the molecular basis underlying phenotypic diversity. A long-standing hypothesis states that species-specific traits may be explained by differences in gene regulation rather than differences at the protein level. Over the past few years, evolutionary studies have shifted from mere sequence comparisons to integrative analyses in which gene regulation is key to understanding species evolution. DNA methylation is an important epigenetic modification involved in the regulation of numerous biological processes. Nevertheless, the evolution of the human methylome and the processes driving such changes are poorly understood. Here, we review the close interplay between Cytosine-phosphate-Guanine (CpG) methylation and the underlying genome sequence, as well as its evolutionary impact. We also summarize the latest advances in the field, revisiting the main literature on human and nonhuman primates. We hope to encourage the scientific community to address the many challenges posed by the field of comparative epigenomics.ca
• dc.description.sponsorship TMB is supported by ICREA (www.icrea.cat), EMBO YIP (www.embo.org) 2013, MICINN BFU2014-55090-P (www.mecd.gob.es), BFU2015-7116-ERC and BFU2015-6215-ERC. AJS is supported by NIH (www.nih.gov) grants DA033660, HG006696, HD073731, and MH097018, and research grant 6-FY13-92 from the March of Dimes Foundation. IHH is supported by AGAUR (Generalitat de Catalunya, Spain; www.gencat.cat/agaur/) and RGP by a fellowship from MICINN (www.mecd.gob.es). We also acknowledge the Barcelona Zoo (Ajuntament de Barcelona) for an award to IHH.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Hernando-Herraez I, Garcia-Perez R, Sharp AJ, Marques-Bonet T. DNA methylation: insights into human evolution. PLoS Genetics. 2015;11(12):e1005661. DOI: 10.1371/journal.pgen.1005661ca
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pgen.1005661
• dc.identifier.issn 1553-7390
• dc.identifier.uri http://hdl.handle.net/10230/25687
• dc.language.iso engca
• dc.publisher Public Library of Science (PLoS)ca
• dc.relation.ispartof PLoS Genetics. 2015;11(12):e1005661
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-55090-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-7116
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-6215
• dc.rights © 2015 Hernando-Herraez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
• dc.subject.other Genètica evolutivaca
• dc.subject.other Ximpanzés -- Genèticaca
• dc.title DNA methylation: insights into human evolutionca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca