Structural brain differences in the Alzheimer's Disease Continuum: Insights into the heterogeneity from a large multisite neuroimaging consortium
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- dc.contributor.author Evans, Tavia E.
- dc.contributor.author Vilor Tejedor, Natàlia, 1988-
- dc.contributor.author Operto, Grégory
- dc.contributor.author Falcón, Carles
- dc.contributor.author Hofman, Albert
- dc.contributor.author Ibañez, Agustin
- dc.contributor.author Seshadari, Sudha
- dc.contributor.author Tan, Louis C. S.
- dc.contributor.author Weiner, Michael W.
- dc.contributor.author Alladi, Suverna
- dc.contributor.author Anazodo, Udunna
- dc.contributor.author Gispert López, Juan Domingo
- dc.contributor.author Alzheimer’s Disease Neuroimaging Initiative
- dc.contributor.author Australian Imaging Biomarkers and Lifestyle flagship study of ageing
- dc.contributor.author Adams, Hieab H.
- dc.date.accessioned 2025-01-22T07:23:05Z
- dc.date.available 2025-01-22T07:23:05Z
- dc.date.issued 2024
- dc.description Data de publicació electrònica: 30-07-2024
- dc.description.abstract Background: Neurodegenerative diseases require collaborative, multisite research to comprehensively grasp their complex and diverse pathological progression; however, there is caution in aggregating global data due to data heterogeneity. In the current study, we investigated brain structure across stages of Alzheimer's disease (AD) and how relationships vary across sources of heterogeneity. Methods: Using 6 international datasets (N > 27,000), associations of structural neuroimaging markers were investigated in relation to the AD continuum via meta-analysis. We investigated whether associations varied across elements of magnetic resonance imaging acquisition, study design, and populations. Results: Modest differences in associations were found depending on how data were acquired; however, patterns were similar. Preliminary results suggested that neuroimaging marker-AD relationships differ across ethnic groups. Conclusions: Diversity in data offers unique insights into the neural substrate of AD; however, harmonized processing and transparency of data collection are needed. Global collaborations should embrace the inherent heterogeneity that exists in the data and quantify its contribution to research findings at the meta-analytical stage.
- dc.format.mimetype application/pdf
- dc.identifier.citation Evans TE, Vilor-Tejedor N, Operto G, Falcon C, Hofman A, Ibáñez A, et al. Structural brain differences in the Alzheimer's Disease Continuum: Insights into the heterogeneity from a large multisite neuroimaging consortium. Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Jul 30:S2451-9022(24)00207-6. DOI: 10.1016/j.bpsc.2024.07.019
- dc.identifier.doi http://dx.doi.org/10.1016/j.bpsc.2024.07.019
- dc.identifier.issn 2451-9022
- dc.identifier.uri http://hdl.handle.net/10230/69228
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Jul 30:S2451-9022(24)00207-6
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/283562
- dc.rights © 2024 Society of Biological Psychiatry. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Alzheimer’s disease
- dc.subject.keyword Diversity
- dc.subject.keyword Heterogeneity
- dc.subject.keyword Imaging
- dc.subject.keyword MRI
- dc.subject.keyword Multisite
- dc.title Structural brain differences in the Alzheimer's Disease Continuum: Insights into the heterogeneity from a large multisite neuroimaging consortium
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion