GENCODE 2021

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  • dc.contributor.author Frankish, Adam
  • dc.contributor.author Lagarde, Julien
  • dc.contributor.author Carbonell Sala, Silvia
  • dc.contributor.author Guigó Serra, Roderic
  • dc.contributor.author Flicek, Paul
  • dc.date.accessioned 2021-02-16T07:02:19Z
  • dc.date.available 2021-02-16T07:02:19Z
  • dc.date.issued 2021
  • dc.description.abstract The GENCODE project annotates human and mouse genes and transcripts supported by experimental data with high accuracy, providing a foundational resource that supports genome biology and clinical genomics. GENCODE annotation processes make use of primary data and bioinformatic tools and analysis generated both within the consortium and externally to support the creation of transcript structures and the determination of their function. Here, we present improvements to our annotation infrastructure, bioinformatics tools, and analysis, and the advances they support in the annotation of the human and mouse genomes including: the completion of first pass manual annotation for the mouse reference genome; targeted improvements to the annotation of genes associated with SARS-CoV-2 infection; collaborative projects to achieve convergence across reference annotation databases for the annotation of human and mouse protein-coding genes; and the first GENCODE manually supervised automated annotation of lncRNAs. Our annotation is accessible via Ensembl, the UCSC Genome Browser and https://www.gencodegenes.org.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Frankish A, Diekhans M, Jungreis I, Lagarde J, Loveland JE, Mudge JM et al. GENCODE 2021. Nucleic Acids Res. 2021; 49(D1):D916-D923. DOI: 10.1093/nar/gkaa1087
  • dc.identifier.doi http://dx.doi.org/10.1093/nar/gkaa1087
  • dc.identifier.issn 0305-1048
  • dc.identifier.uri http://hdl.handle.net/10230/46485
  • dc.language.iso eng
  • dc.publisher Oxford University Press
  • dc.relation.ispartof Nucleic Acids Res. 2021; 49(D1):D916-D923
  • dc.rights © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.title GENCODE 2021
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Center for Genomic Regulation (CRG))