Genomic profiling in advanced stage non-small-cell lung cancer patients with platinum-based chemotherapy identifies germline variants with prognostic value in SMYD2
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- dc.contributor.author Galván-Femenía, Iván
- dc.contributor.author Guindo Martínez, Marta
- dc.contributor.author Duran Jordà, Xavier, 1974-
- dc.contributor.author Calabuig-Fariñas, Sílvia
- dc.contributor.author Mercader Bigas, Josep Maria
- dc.contributor.author Ramirez, Jose Luis
- dc.contributor.author Rosell, Rafael
- dc.contributor.author Torrents, David
- dc.contributor.author Carreras, Anna
- dc.contributor.author Kohno, Takashi
- dc.contributor.author Jantus-Lewintre, Eloisa
- dc.contributor.author Camps, Carlos
- dc.contributor.author Perucho, Manuel
- dc.contributor.author Sumoy Van Dyck, Lauro
- dc.contributor.author Yokota, Jun
- dc.contributor.author Cid Ibeas, Rafael de
- dc.date.accessioned 2019-06-04T07:30:44Z
- dc.date.available 2019-06-04T07:30:44Z
- dc.date.issued 2018
- dc.description.abstract Objective: The aim of the study was to investigate the relationship between germline variations as a prognosis biomarker in patients with advanced Non-Small-Cell-Lung-Cancer (NSCLC) subjected to first-line platinum-based treatment. Materials and Methods: We carried out a two-stage genome-wide-association study in non-small-cell lung cancer patients with platinum-based chemotherapy in an exploratory sample of 181 NSCLC patients from Caucasian origin, followed by a validation on 356 NSCLC patients from the same ancestry (Valencia, Spain). Results: We identified germline variants in SMYD2 as a prognostic factor for survival in patients with advanced NSCLC receiving chemotherapy. SMYD2 alleles are associated to a decreased overall survival and with a reduced Time to Progression. In addition, enrichment pathway analysis identified 361 variants in 40 genes to be involved in poorer outcome in advanced-stage NSCLC patients. Conclusion: Germline SMYD2 alleles are associated with bad clinical outcome of first-line platinum-based treatment in advanced NSCLC patients. This result supports the role of SMYD2 in the carcinogenic process, and might be used as prognostic signature directing patient stratification and the choice of therapy. Microabstract: A two-Stage Genome wide association study in Caucasian population reveals germline genetic variation in SMYD2 associated to progression disease in first-line platinum-based treatment in advanced NSCLC patients. SMYD2 profiling might have prognostic / predictive value directing choice of therapy and enlighten current knowledge on pathways involved in human carcinogenesis as well in resistance to chemotherapy.
- dc.format.mimetype application/pdf
- dc.identifier.citation Galván-Femenía I, Guindo M, Duran X, Calabuig-Fariñas S, Mercader JM, Ramirez JL, Rosell R, Torrents D, Carreras A, Kohno T, Jantus-Lewintre E, Camps C, Perucho M, Sumoy L, Yokota J, de Cid R. Genomic profiling in advanced stage non-small-cell lung cancer patients with platinum-based chemotherapy identifies germline variants with prognostic value in SMYD2. Cancer Treat Res Commun. 2018;15:21-31. DOI 10.1016/j.ctarc.2018.02.003
- dc.identifier.doi http://dx.doi.org/10.1016/j.ctarc.2018.02.003
- dc.identifier.issn 2468-2942
- dc.identifier.uri http://hdl.handle.net/10230/41694
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Cancer Treat Res Commun. 2018;15:21-31
- dc.rights © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/)
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/BY-NC-ND/4.0/
- dc.subject.keyword Lung cancer
- dc.subject.keyword NSCLC
- dc.subject.keyword Advanced stage
- dc.subject.keyword Prognostic factors
- dc.subject.keyword Genome-Wide-Association Studies
- dc.title Genomic profiling in advanced stage non-small-cell lung cancer patients with platinum-based chemotherapy identifies germline variants with prognostic value in SMYD2
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion