Neurodegeneration and cancer: where the disorder prevails
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- dc.contributor.author Klus, Petr, 1985-ca
- dc.contributor.author Cirillo, Davideca
- dc.contributor.author Botta Orfila, Teresaca
- dc.contributor.author Tartaglia, Gian Gaetanoca
- dc.date.accessioned 2018-05-11T09:18:56Z
- dc.date.available 2018-05-11T09:18:56Z
- dc.date.issued 2015
- dc.description.abstract It has been reported that genes up-regulated in cancer are often down-regulated in neurodegenerative disorders and vice versa. The fact that apparently unrelated diseases share functional pathways suggests a link between their etiopathogenesis and the properties of molecules involved. Are there specific features that explain the exclusive association of proteins with either cancer or neurodegeneration? We performed a large-scale analysis of physico-chemical properties to understand what characteristics differentiate classes of diseases. We found that structural disorder significantly distinguishes proteins up-regulated in neurodegenerative diseases from those linked to cancer. We also observed high correlation between structural disorder and age of onset in Frontotemporal Dementia, Parkinson's and Alzheimer's diseases, which strongly supports the role of protein unfolding in neurodegenerative processes.
- dc.description.sponsorship The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013), through the European Research Council, under grant agreement RIBOMYLOME_309545 (Gian Gaetano Tartaglia), and from the Fundació La Marató de TV3 (20142731). We also acknowledge support from AGAUR (2014 SGR00685) and the Spanish Ministry of Economy and Competitiveness (BFU2014-55054-P), ‘Centro de Excelencia Severo Ochoa 2013-2017′ (SEV-2012-0208)
- dc.format.mimetype application/pdf
- dc.identifier.citation Klus P, Cirillo D, Botta Orfila T, Gaetano Tartaglia G. Neurodegeneration and cancer: where the disorder prevails. Sci Rep. 2015;5:15390. DOI: 10.1038/srep15390
- dc.identifier.doi http://dx.doi.org/10.1038/srep15390
- dc.identifier.issn 2045-2322
- dc.identifier.uri http://hdl.handle.net/10230/34616
- dc.language.iso eng
- dc.publisher Nature Publishing Groupca
- dc.relation.ispartof Scientific Reports. 2015;5:15390
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/309545
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-55054-P
- dc.rights © Nature Publishing Group. http://dx.doi.org/10.1038/srep15390. Creative Commons Attribution 4.0 International License
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.other Tumors
- dc.subject.other Sistema nerviós -- Degeneració
- dc.title Neurodegeneration and cancer: where the disorder prevailsca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion