Associations of exposure to outdoor PM2.5 and NO2 during pregnancy with childhood asthma, rhinitis, and eczema in a predominantly rural French mother-child cohort

Patlán-Hernández, Alan R.; Savouré, Marine; Audureau, Etienne; Monfort, Christine; de Castro, Montserrat; Epaud, Ralph; de Hoogh, Kees; Hough, Ian; Kloog, Itai; Lanone, Sophie; Lepeule, Johanna; Nieuwenhuijsen, Mark J.; Vienneau, Danielle; Warembourg, Charline; Chevrier, Cécile; Jacquemin Leonard, Bénédicte

Associations of exposure to outdoor PM2.5 and NO2 during pregnancy with childhood asthma, rhinitis, and eczema in a predominantly rural French mother-child cohort

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dc.contributor.author Patlán-Hernández, Alan R.
dc.contributor.author Savouré, Marine
dc.contributor.author Audureau, Etienne
dc.contributor.author Monfort, Christine
dc.contributor.author de Castro, Montserrat
dc.contributor.author Epaud, Ralph
dc.contributor.author de Hoogh, Kees
dc.contributor.author Hough, Ian
dc.contributor.author Kloog, Itai
dc.contributor.author Lanone, Sophie
dc.contributor.author Lepeule, Johanna
dc.contributor.author Nieuwenhuijsen, Mark J.
dc.contributor.author Vienneau, Danielle
dc.contributor.author Warembourg, Charline
dc.contributor.author Chevrier, Cécile
dc.contributor.author Jacquemin Leonard, Bénédicte
dc.date.accessioned 2025-01-15T07:26:36Z
dc.date.available 2025-01-15T07:26:36Z
dc.date.issued 2024
dc.description.abstract Uncertainty remains regarding the effects of outdoor air pollution in rural areas on childhood asthma, rhinitis, and eczema. Although these diseases often coexist, few studies have examined the effects of air pollution on their multimorbidity. The objective of this study was to investigate the associations of pregnancy exposure to outdoor fine particulate matter (PM2.5) and nitrogen dioxide (NO2) with childhood asthma, rhinitis, eczema, and their multimorbidity. We included children from the 6-year (n = 1322) and 12-year (n = 1118) follow-up of the Pélagie mother-child cohort in Brittany, France where 64% of the participants lived in rural areas. Asthma, rhinitis, eczema, and a multimorbidity phenotype (concomitant presence of ≥2 diseases) were defined by validated questionnaires. PM2.5 and NO2 concentrations during pregnancy were modeled at residential address using land use regression. We assessed associations using logistic regressions per interquartile range (PM2.5: 3 μg/m3; NO2: 10 μg/m3). We also performed stratification by type of area (urban and rural). Asthma, rhinitis, eczema, and the multimorbidity phenotype prevalence were 12%, 20%, 22% and 12% at 6-years, and 10%, 23%, 19% and 11% at 12-years of follow-up. At 6-years, for eczema, a tendency of an association was observed with NO2 (OR = 1.15, 95% CI = 0.97-1.36, p-value = 0.10), and stratification by type of area showed statistically significant associations for PM2.5 (1.49 (1.03-2.13), p = 0.03) and NO2 (1.40 (1.08-1.82), p = 0.01) in the urban stratum. At 12-years, main analyses showed a tendency of associations of PM2.5 (1.38 (0.98-1.93), p = 0.07) and NO2 (1.25 (0.98-1.59), p = 0.07) with asthma, and of NO2 with the multimorbidity phenotype (1.23 (0.97-1.56), p = 0.09). While overall results were not statistically significant, associations in urban settings were stronger than in rural ones at 6-years suggesting that possible differences between the effects in urban and rural areas should be further explored.
dc.description.sponsorship This work is part of the REMEDIA project funded by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874753.
dc.format.mimetype application/pdf
dc.identifier.citation Patlán-Hernández AR, Savouré M, Audureau E, Monfort C, de Castro M, Epaud R, et al. Associations of exposure to outdoor PM2.5 and NO2 during pregnancy with childhood asthma, rhinitis, and eczema in a predominantly rural French mother-child cohort. Environ Pollut. 2024 Dec 15;363(Pt 2):125206. DOI: 10.1016/j.envpol.2024.125206
dc.identifier.doi http://dx.doi.org/10.1016/j.envpol.2024.125206
dc.identifier.issn 0269-7491
dc.identifier.uri http://hdl.handle.net/10230/69130
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environ Pollut. 2024 Dec 15;363(Pt 2):125206
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874753
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.subject.keyword Asthma
dc.subject.keyword Children
dc.subject.keyword Eczema
dc.subject.keyword Outdoor air pollution
dc.subject.keyword Rhinitis
dc.subject.keyword Urbanization degree
dc.title Associations of exposure to outdoor PM2.5 and NO2 during pregnancy with childhood asthma, rhinitis, and eczema in a predominantly rural French mother-child cohort
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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