Early smoking-onset age and risk of cardiovascular disease and mortality

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• dc.contributor.author Fa-Binefa, Manel
• dc.contributor.author Clará Velasco, Alberto
• dc.contributor.author Pérez-Fernández, Silvia
• dc.contributor.author Grau Magaña, Maria
• dc.contributor.author Dégano, Irene R.
• dc.contributor.author Martí-Lluch, Ruth
• dc.contributor.author Ramos, Rafel
• dc.contributor.author Marrugat de la Iglesia, Jaume
• dc.contributor.author Elosua Llanos, Roberto
• dc.date.accessioned 2020-03-31T07:44:51Z
• dc.date.issued 2019
• dc.description.abstract Early smoking onset age (SOA) is a public health concern with scant empirical evidence of its role in health outcomes. The study had two aims: i) to assess whether an early SOA was associated with the risk of fatal and non-fatal CVD and all-cause and CVD mortality and ii) to explore the linear and non-linear association between SOA and the outcomes of interest. Data from 4499 current or former smokers, recruited from 1995 to 2005, aged 25 to 79 years, and with a median 7.02 years of follow-up, were obtained from the REGICOR population-based cohort. In the present analysis, performed in 2018, the independent variable was SOA and the dependent variables were CVD events, CVD mortality, and all-cause mortality. Penalized smoothing spline methods were used to assess the linear and non-linear association. During follow-up, 361 deaths and 210 CVD events were recorded. A significant non-linear component was identified in the association between SOA and CVD outcomes with a cut-off point at 12 years: In the group aged ≤12 years, each year of delay in SOA was inversely associated with CVD risk (HR = 0.71; 95%CI = 0.53-0.96) and CVD mortality (HR = 0.58; 95%CI = 0.37-0.90). No association was observed in the older SOA group. A linear association was observed between SOA and all-cause mortality, and each year of delay was associated with 4% lower risk of mortality (HR = 0.96; 95%CI = 0.93-0.98). The associations were adjusted for lifelong exposure to tobacco and cardiovascular risk factors. These results reinforce the value of preventing tobacco use among teenagers and adolescents.
• dc.format.mimetype application/pdf
• dc.identifier.citation Fa-Binefa M, Clará A, Pérez-Fernández S, Grau M, Dégano IR, Marti-Lluch R, et al. Early smoking-onset age and risk of cardiovascular disease and mortality. Prev Med. 2019 Jul; 124:17-22. DOI: 10.1016/j.ypmed.2019.04.022
• dc.identifier.doi http://dx.doi.org/10.1016/j.ypmed.2019.04.022
• dc.identifier.issn 0091-7435
• dc.identifier.uri http://hdl.handle.net/10230/44118
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Preventive Medicine. 2019 Jul;124:17-22
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.ypmed.2019.04.022
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Cardiovascular diseases
• dc.subject.keyword Cardiovascular risk
• dc.subject.keyword Mortality
• dc.subject.keyword Smoking
• dc.subject.keyword Smoking onset age
• dc.subject.keyword Youth
• dc.title Early smoking-onset age and risk of cardiovascular disease and mortality
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion