Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: an exploratory nutrigenomics study
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- dc.contributor.author Khymenets, Olha, 1974-ca
- dc.contributor.author Fitó Colomer, Montserratca
- dc.contributor.author Covas Planells, Maria Isabelca
- dc.contributor.author Farré Albaladejo, Magíca
- dc.contributor.author Pujadas, María Antoniaca
- dc.contributor.author Muñoz Aguayo, Danielca
- dc.contributor.author Konstantinidou, Valentinica
- dc.contributor.author Torre Fornell, Rafael de laca
- dc.date.accessioned 2012-01-31T10:29:45Z
- dc.date.available 2012-01-31T10:29:45Z
- dc.date.issued 2009ca
- dc.description.abstract Virgin olive oil (VOO) is considered to be one of the main components responsible for the health benefits of the Mediterranean diet, particularly against atherosclerosis where peripheral blood mononuclear cells (PBMNCs) play a crucial role in atherosclerosis development and progression. The objective of this article was to identify the PBMNC genes that respond to VOO consumption in order to ascertain the molecular mechanisms underlying the beneficial action of VOO in the prevention of atherosclerosis. Gene expression profiles of PBMNCs from healthy individuals were examined in pooled RNA samples by microarrays after 3 weeks of moderate and regular consumption of VOO, as the main fat source in a diet controlled for antioxidant content. Gene expression was verified by qPCR. The response to VOO consumption was confirmed for individual samples (n = 10) by qPCR for 10 upregulated genes (ADAM17, ALDH1A1, BIRC1, ERCC5, LIAS, OGT, PPARBP, TNFSF10, USP48, and XRCC5). Their putative role in the molecular mechanisms involved in atherosclerosis development and progression is discussed, focusing on a possible relation with VOO consumption. Our data support the hypothesis that 3 weeks of nutritional intervention with VOO supplementation, at doses common in the Mediterranean diet, can alter the expression of genes related to atherosclerosis development and progression.en
- dc.description.sponsorship The CNS Contract CP06/00100 (Montserrat Fitó) is acknowledged. This work has been supported by CICYT (SAF 2004-08173-C03-00) and partially supported by the Generalitat of Catalunya (2005 SGR 0057).en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Khymenets O, Fitó M, Covas M I, Farré M, Pujadas M A, Muñoz D, Konstantinidou V, De la Torre R. Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: an exploratory nutrigenomics study. OMICS: a journal of integrative biology. 2009;13(1):7-19. DOI: 10.1089/omi.2008.0079
- dc.identifier.doi http://dx.doi.org/10.1089/omi.2008.0079
- dc.identifier.issn 1536-2310
- dc.identifier.uri http://hdl.handle.net/10230/16183
- dc.language.iso engca
- dc.publisher Mary Ann Liebert, Incca
- dc.relation.ispartof OMICS: a journal of integrative biology. 2009;13(1):7-19
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/SAF2004-08173
- dc.rights This is a copy of an article published in the OMICS: a journal of integrative biology © 2009 copyright Mary Ann Liebert, Inc.; OMICS: a journal of integrative biology is available online at: http://www.liebertonline.com.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Virgin olive oilen
- dc.subject.keyword VOOen
- dc.subject.keyword Mediterranean dieten
- dc.subject.keyword Atherosclerosisen
- dc.subject.keyword Peripheral blood mononuclear cellsen
- dc.subject.keyword PBMNC genesen
- dc.subject.keyword Nutrigenomicsen
- dc.subject.other Oli d'olivaca
- dc.subject.other Arteriosclerosi -- Prevencióca
- dc.subject.other Dieta mediterràniaca
- dc.subject.other Nutricióca
- dc.subject.other Genòmicaca
- dc.subject.other Genèticaca
- dc.title Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: an exploratory nutrigenomics studyca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionen