Specific IgA and CLA + T-Cell IL-17 response to streptococcus pyogenes in psoriasis

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• dc.contributor.author de Jesús-Gil, Carmen
• dc.contributor.author Sans-de San Nicolás, Lídia
• dc.contributor.author Ruiz-Romeu, Ester
• dc.contributor.author Ferran Farrés, Marta
• dc.contributor.author Soria-Martinez, Laura
• dc.contributor.author Chiriac, Anca
• dc.contributor.author Celada, Antonio
• dc.contributor.author Pujol Vallverdú, Ramon Maria
• dc.contributor.author Santamaría-Babí, Luis Francisco
• dc.date.accessioned 2021-04-13T06:46:21Z
• dc.date.issued 2020
• dc.description.abstract Streptococcus pyogenes tonsillar infection is well known to trigger and exacerbate psoriasis lesions in both guttate and plaque forms of the disease. Although mucosal and cutaneous tissues are closely involved in psoriasis pathology, the interaction between their specific immune responses has not been deeply explored. This work aims to address and characterize the presence of humoral responses against S. pyogenes in patients with psoriasis and its putative association with cytokine responses detected in vitro in our psoriasis ex vivo model, based on the coculture of cutaneous lymphocyte-associated antigen+/- T cells with autologous epidermal cells. Patients with psoriasis presented increased IgA response to S. pyogenes when compared with control subjects. In patients with plaque psoriasis, despite being negative for anti-streptolysin O antibody titer, IgA plasma levels against S. pyogenes correlated with cutaneous lymphocyte-associated antigen+ T-cell-dependent IL-17F response in vitro. No association is observed for IgG levels in plaque psoriasis. Similar association is observed for IgA anti-S. pyogenes extract and IL-17A in patients with guttate psoriasis. We propose S. pyogenes-specific IgA as a potential new perspective for better understanding the role of S. pyogenes in psoriasis development.
• dc.format.mimetype application/pdf
• dc.identifier.citation De Jesús-Gil C, Sans-de San Nicolás L, Ruiz-Romeu E, Ferran M, Soria-Martinez L, Chiriac A, et al. Specific IgA and CLA + T-Cell IL-17 response to streptococcus pyogenes in psoriasis. J Invest Dermatol. 2020 Jul; 140(7): 1364-70.e1. DOI: 10.1016/j.jid.2019.12.022
• dc.identifier.doi http://dx.doi.org/10.1016/j.jid.2019.12.022
• dc.identifier.issn 0022-202X
• dc.identifier.uri http://hdl.handle.net/10230/47093
• dc.language.iso eng
• dc.publisher Elsevier
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.jid.2019.12.022
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Psoriasi
• dc.subject.other Estreptococs
• dc.subject.other Streptococcus pyogenes extract
• dc.subject.other Cutaneous lymphocyte antigen
• dc.subject.other Phosphate buffered saline
• dc.subject.other T helper type 17
• dc.title Specific IgA and CLA + T-Cell IL-17 response to streptococcus pyogenes in psoriasis
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion