Histological deep margins in cutaneous squamous cell carcinoma of the scalp and risk of recurrence
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- dc.contributor.author Verdaguer-Faja, Júlia
- dc.contributor.author Guerra-Amor, Álvaro
- dc.contributor.author Ferrándiz-Pulido, Carla
- dc.contributor.author Abril-Pérez, Carlos
- dc.contributor.author Botella Estrada, Rafael
- dc.contributor.author Masferrer, Emili
- dc.contributor.author López-Castillo, Daniel
- dc.contributor.author Deza Vargas, Luis Gustavo
- dc.contributor.author Leal, Lorena
- dc.contributor.author Marti-Marti, Ignasi
- dc.contributor.author Ruiz-Salas, Verónica
- dc.contributor.author Yébenes, Mireia
- dc.contributor.author Marqués Martin, Laura
- dc.contributor.author Baliu, Carola
- dc.contributor.author Castany, Anna
- dc.contributor.author Boada, Aram
- dc.contributor.author Toll Abelló, Agustín
- dc.contributor.author Jaka, Ane
- dc.date.accessioned 2025-07-22T06:49:10Z
- dc.date.available 2025-07-22T06:49:10Z
- dc.date.issued 2025
- dc.description.abstract Background: Consensus is lacking on adequate deep histological margins in cutaneous squamous cell carcinoma (cSCC). Deep clearance for tumours located on the scalp is limited by anatomic constraints. Objective: To determine whether clear but close deep histological margins (<1 mm) confer a higher risk of recurrence in cSCCs of the scalp treated by wide local excision, compared to deep histological margins ≥1 mm. Methods: Multicentre retrospective observational cohort study and multivariate competing risk analysis to evaluate risk factors for recurrence. Results: In total, 295 patients with 338 cSCCs were included. Close deep histological margins were not associated with an increased cumulative incidence of recurrence (subhazard ratio [SHR] 1.96 [95% CI 0.87-4.41]). However, an increased risk of recurrence was observed for those tumours that presented concurrent invasion of the galea aponeurotica and close deep margins, as opposed to patients without these factors (SHR 3.52 [1.24-10.01]). Tumours with clear but close peripheral margins (<1 mm) also had higher risk of recurrence (SHR 5.01 [1.68-14.97]). Limitations: Retrospective observational study based on pathology reports. Conclusions: Deep histological margins <1 mm do not confer a greater risk of recurrence as long as the tumour is completely excised and the galea aponeurotica is not involved. Surgical excision of cSCC on the scalp should include the galea to ensure proper assessment of deep margins.
- dc.format.mimetype application/pdf
- dc.identifier.citation Verdaguer-Faja J, Guerra-Amor Á, Ferrándiz-Pulido C, Abril-Pérez C, Botella Estrada R, Masferrer E, et al. Histological deep margins in cutaneous squamous cell carcinoma of the scalp and risk of recurrence. J Eur Acad Dermatol Venereol. 2025 Apr;39(4):855-64. DOI: 10.1111/jdv.20250
- dc.identifier.doi http://dx.doi.org/10.1111/jdv.20250
- dc.identifier.issn 0926-9959
- dc.identifier.uri http://hdl.handle.net/10230/70964
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof J Eur Acad Dermatol Venereol. 2025 Apr;39(4):855-64
- dc.rights © 2024 The Author(s). Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.other Tumors
- dc.subject.other Cuir cabellut--Malalties
- dc.title Histological deep margins in cutaneous squamous cell carcinoma of the scalp and risk of recurrence
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion