Outcomes of frail patients while waiting for kidney transplantation: differences between physical frailty phenotype and FRAIL scale

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  • dc.contributor.author Pérez-Sáez, María José
  • dc.contributor.author Redondo Pachón, María Dolores
  • dc.contributor.author Arias Cabrales, Carlos Enrique
  • dc.contributor.author Faura, Anna
  • dc.contributor.author Bach Pascual, Anna
  • dc.contributor.author Buxeda, Anna
  • dc.contributor.author Burballa Tàrrega, Carla, 1988-
  • dc.contributor.author Junyent-Iglesias, Ernestina
  • dc.contributor.author Crespo Barrio, Marta
  • dc.contributor.author Marco Navarro, Ester
  • dc.contributor.author Rodríguez-Mañas, Leocadio
  • dc.contributor.author Pascual Santos, Julio
  • dc.date.accessioned 2022-09-30T05:51:25Z
  • dc.date.available 2022-09-30T05:51:25Z
  • dc.date.issued 2022
  • dc.description.abstract Frailty is associated with poorer outcomes among patients waiting for kidney transplantation (KT). Several different tools to measure frailty have been used; however, their predictive value is unknown. This is a prospective longitudinal study of 449 KT candidates evaluated for frailty by the Physical Frailty Phenotype (PFP) and the FRAIL scale. During the study period, 296 patients received a KT, while 153 remained listed. Patients who did not get receive a transplant were more frequently frail according to PFP (16.3 vs. 7.4%, p = 0.013). Robust patients had fewer hospital admissions during the 1st year after listing (20.8% if PFP = 0 vs. 43.4% if ≥1, and 27.1% if FRAIL = 0 vs. 48.9% if ≥1) and fewer cardiovascular events (than FRAIL ≥ 1) or major infectious events (than PFP ≥ 1). According to PFP, scoring 1 point had an impact on patient survival and chance of transplantation in the univariate analysis. The multivariable analysis corroborated the result, as candidates with PFP ≥ 3 had less likelihood of transplantation (HR 0.45 [0.26-0.77]). The FRAIL scale did not associate with any of these outcomes. In KT candidates, pre-frailty and frailty according to both the PFP and the FRAIL scale were associated with poorer results while listed. The PFP detected that frail patients were less likely to receive a KT, while the FRAIL scale did not.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Pérez-Sáez MJ, Redondo-Pachón D, Arias-Cabrales CE, Faura A, Bach A, Buxeda A, Burballa C, Junyent E, Crespo M, Marco E, Rodríguez-Mañas L, Pascual J. Outcomes of frail patients while waiting for kidney transplantation: differences between physical frailty phenotype and FRAIL scale. J Clin Med. 2022 Jan 28;11(3):672. DOI: 10.3390/jcm11030672
  • dc.identifier.doi http://dx.doi.org/10.3390/jcm11030672
  • dc.identifier.issn 2077-0383
  • dc.identifier.uri http://hdl.handle.net/10230/54231
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.ispartof J Clin Med. 2022 Jan 28;11(3):672
  • dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword FRAIL
  • dc.subject.keyword Frailty
  • dc.subject.keyword Kidney transplant waiting list
  • dc.title Outcomes of frail patients while waiting for kidney transplantation: differences between physical frailty phenotype and FRAIL scale
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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