Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial
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- dc.contributor.author Papadaki, Angelikica
- dc.contributor.author Martínez-González, Miguel Ángel, 1957-ca
- dc.contributor.author Alonso-Gómez, Ángelca
- dc.contributor.author Rekondo, Javierca
- dc.contributor.author Salas-Salvadó, Jordica
- dc.contributor.author Corella, Doloresca
- dc.contributor.author Ros, Emilioca
- dc.contributor.author Fitó Colomer, Montserratca
- dc.contributor.author Estruch, Ramónca
- dc.contributor.author Lapetra, Joséca
- dc.contributor.author García-Rodriguez, Antonioca
- dc.contributor.author Fiol, Miquelca
- dc.contributor.author Serra Majem, Lluísca
- dc.contributor.author Pintó Sala, Xavierca
- dc.contributor.author Ruiz-Canela, Miguelca
- dc.contributor.author Bulló, Mònicaca
- dc.contributor.author Serra-Mir, Mercèca
- dc.contributor.author Sorlí, José Vicenteca
- dc.contributor.author Arós, Fernandoca
- dc.date.accessioned 2018-01-10T08:24:45Z
- dc.date.issued 2017
- dc.description.abstract AIMS: The aim of this study was to evaluate the effect of the Mediterranean diet (MedDiet) on the incidence of heart failure (HF), a pre-specified secondary outcome in the PREDIMED (PREvención con DIeta MEDiterránea) primary nutrition-intervention prevention trial. METHODS AND RESULTS: Participants at high risk of cardiovascular disease were randomly assigned to one of three diets: MedDiet supplemented with extra-virgin olive oil (EVOO), MedDiet supplemented with nuts, or a low-fat control diet. Incident HF was ascertained by a Committee for Adjudication of events blinded to group allocation. Among 7403 participants without prevalent HF followed for a median of 4.8 years, we observed 29 new HF cases in the MedDiet with EVOO group, 33 in the MedDiet with nuts group, and 32 in the control group. No significant association with HF incidence was found for the MedDiet with EVOO and MedDiet with nuts, compared with the control group [hazard ratio (HR) 0.68; 95% confidence interval (CI) 0.41-1.13, and HR 0.92; 95% CI 0.56-1.49, respectively]. CONCLUSION: In this sample of adults at high cardiovascular risk, the MedDiet did not result in lower HF incidence. However, this pre-specified secondary analysis may have been underpowered to provide valid conclusions. Further randomized controlled trials with HF as a primary outcome are needed to better assess the effect of the MedDiet on HF risk.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Papadaki A, Martínez-González MÁ, Alonso-Gómez A, Rekondo J, Salas-Salvadó J, Corella D. et al. Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial. Eur J Heart Fail. 2017 Sep;19(9):1179-1185. DOI: 10.1002/ejhf.750
- dc.identifier.doi http://dx.doi.org/10.1002/ejhf.750
- dc.identifier.issn 1388-9842
- dc.identifier.uri http://hdl.handle.net/10230/33606
- dc.language.iso eng
- dc.publisher Wileyca
- dc.relation.ispartof European Journal of Heart Failure. 2017 Sep;19(9):1179-85
- dc.rights This is the peer reviewed version of the following article: Papadaki A, Martínez-González MÁ, Alonso-Gómez A, Rekondo J, Salas-Salvadó J, Corella D. et al. Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial. Eur J Heart Fail. 2017 Sep;19(9):1179-1185, which has been published in final form at http://dx.doi.org/10.1002/ejhf.750. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Cardiovascular disease
- dc.subject.keyword Heart failure
- dc.subject.keyword Mediterranean diet
- dc.subject.other Infart de miocardi
- dc.subject.other Dieta -- Mediterrània, Regió de la
- dc.title Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trialca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion