Temporal and spatial expression of CCN genes in zebrafish
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- dc.contributor.author Fernando, Carol A.ca
- dc.contributor.author Conrad, Patricia A.ca
- dc.contributor.author Bartels, Cynthia F.ca
- dc.contributor.author Marquès i Bonet, Tomàs, 1975-ca
- dc.contributor.author To, Michaelca
- dc.contributor.author Balow, Stephanie A.ca
- dc.contributor.author Nakamura, Yukioca
- dc.contributor.author Warman, Matthew L.ca
- dc.date.accessioned 2016-01-11T15:26:35Z
- dc.date.available 2016-01-11T15:26:35Z
- dc.date.issued 2010
- dc.description.abstract The six mammalian CCN genes (Cyr61, CTGF, Nov, WISP1, WISP2, WISP3) encode a family of secreted, cysteine-rich, multimodular proteins having roles in cell proliferation, adhesion, migration, and differentiation during embryogenesis, wound healing, and angiogenesis. We used bioinformatics to identify 9 CCN genes in zebrafish (zCCNs), 6 of which have not been previously described. When compared with mammalian CCN family members, 3 were paralogs of Cyr61, 2 of CTGF, 2 of WISP1, 1 of WISP2, and 1 of WISP3. No paralog of Nov was found. In situ hybridization was performed to characterize the sites of expression of the zCCNs during early zebrafish development. zCCNs demonstrated both unique and overlapping patterns of expression, suggesting potential division of labor between orthologous genes and providing an alternate approach to gene function studies that will complement studies in mammalian models.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Fernando CA, Conrad PA, Bartels CF, Marques T, To M, Balow SA et al. Temporal and spatial expression of CCN genes in zebrafish. Developmental dynamics. 2010;239(6):1755-67. DOI: 10.1002/dvdy.22279ca
- dc.identifier.doi http://dx.doi.org/10.1002/dvdy.22279
- dc.identifier.issn 1058-8388
- dc.identifier.uri http://hdl.handle.net/10230/25552
- dc.language.iso engca
- dc.publisher Wileyca
- dc.relation.ispartof Developmental dynamics. 2010;239(6):1755-67
- dc.rights © 2010 Wiley-Liss, Inc. Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/2.5/ca
- dc.subject.keyword Cyr61
- dc.subject.keyword Cysteine rich protein 61
- dc.subject.keyword CTGF, connective tissue growth factor
- dc.subject.keyword Nov, nephroblastoma overexpressed
- dc.subject.keyword WISP, Wnt-1 inducible signaling pathway protein
- dc.subject.other Peixos zebra -- Genèticaca
- dc.subject.other Proteïnesca
- dc.title Temporal and spatial expression of CCN genes in zebrafishca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca