Population analysis of complete mitogenomes for 334 samples from El Salvador

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  • dc.contributor.author Aizpurua-Iraola, Julen
  • dc.contributor.author Rasal Soteras, Raquel
  • dc.contributor.author Prieto, Lourdes
  • dc.contributor.author Comas, David, 1969-
  • dc.contributor.author Bonet, Núria
  • dc.contributor.author Casals López, Ferran
  • dc.contributor.author Calafell i Majó, Francesc
  • dc.contributor.author Vásquez, Patricia
  • dc.date.accessioned 2023-07-04T06:42:46Z
  • dc.date.available 2023-07-04T06:42:46Z
  • dc.date.issued 2023
  • dc.description.abstract The use of mitochondrial DNA (mtDNA) in the field of forensic genetics is widely spread mainly due to its advantages when identifying highly degraded samples. In this sense, massive parallel sequencing has made the analysis of the whole mitogenome more accessible, noticeably increasing the informativeness of mtDNA haplotypes. The civil war (1980-1992) in El Salvador caused many deaths and disappearances (including children) all across the country and the economic and social instability after the war forced many people to emigration. For this reason, different organizations have collected DNA samples from relatives with the aim of identifying missing people. Thus, we present a dataset containing 334 complete mitogenomes from the Salvadoran general population. To the best of our knowledge, this is the first publication of a nationwide forensic-quality complete mitogenome database of any Latin American country. We found 293 different haplotypes, with a random match probability of 0.0041 and 26.6 mean pairwise differences, which is similar to other Latin American populations, and which represent a marked improvement from the values obtained with just control region sequences. These haplotypes belong to 54 different haplogroups, being 91% of them of Native American origin. Over a third (35.9%) of the individuals carried at least a heteroplasmic site (excluding length heteroplasmies). Ultimately, the present database aims to represent mtDNA haplotype diversity in the general Salvadoran populations as a basis for the identification of people that disappeared during or after the civil war.
  • dc.description.sponsorship This work was supported by the Spanish Ministry of Economy and Competitiveness and Agencia Estatal de Investigación (grant numbers CGL2016-75389-P (MINEICO/FEDER, UE), PID2019-106485GB-I00/AEI/10.13039/501100011033 (MINEICO), and “Unidad María de Maeztu” (MDM-2014-0370) to FCal and DC; Agència de Gestió d’Ajuts Universitaris i de la Recerca (Generalitat de Catalunya, grant 2017SGR00702); Agència Catalana de Cooperació al Desenvolupament (ACCD004/17/00019 and ACCD016/18/00031); Fundación Panamericana para el Desarrollo (PADF, No. PRDHD-RFA-R-2017-009). We thank also the Ministry of Health of El Salvador, which, in 2018, allowed us to take samples at their facilities.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Aizpurua-Iraola J, Rasal R, Prieto L, Comas D, Bonet N, Casals F, Calafell F, Vásquez P. Population analysis of complete mitogenomes for 334 samples from El Salvador. Forensic Sci Int Genet. 2023 Jun 16;66:102906. DOI: 10.1016/j.fsigen.2023.102906
  • dc.identifier.doi http://dx.doi.org/10.1016/j.fsigen.2023.102906
  • dc.identifier.issn 1872-4973
  • dc.identifier.uri http://hdl.handle.net/10230/57454
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Forensic Sci Int Genet. 2023 Jun 16;66:102906
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/CGL2016-75389-P
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-106485GB-I00
  • dc.rights © 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/bync-nd/4.0/
  • dc.subject.keyword El Salvador
  • dc.subject.keyword Mitochondrial DNA
  • dc.subject.keyword Mitogenomes
  • dc.title Population analysis of complete mitogenomes for 334 samples from El Salvador
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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