Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status, tobacco smoking, alcohol drinking and salt intake
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- dc.contributor.author Collatuzzo, Giulia
- dc.contributor.author Castaño Vinyals, Gemma
- dc.contributor.author Boffetta, Paolo
- dc.date.accessioned 2023-02-17T07:04:50Z
- dc.date.available 2023-02-17T07:04:50Z
- dc.date.issued 2022
- dc.description Data de publicació electrònica: 13-07-2022
- dc.description.abstract Background: Peptic ulcer disease (PUD) and gastric cancer (GC) are more prevalent in individuals with low socioeconomic status (SES) and share several risk factors. The aim of this study was to investigate the mediating role of PUD in the association between established risk factors and GC. Methods: We conducted a pooled analysis of 12 studies from the Stomach Cancer Pooling Project Consortium, including a total of 4877 GC cases and 11 808 controls. We explored the mediating role of PUD in the association between SES, tobacco smoking, heavy alcohol drinking and salt intake, and GC. Also, we assessed the ORs and 95% CIs of the risk factors and both PUD and GC. Results: PUD mediated 36% of the smoking effect mainly among men. Other risk factors were only slightly mediated by PUD (SES, 5.3%; heavy alcohol drinking, 3.3%; and salt intake, 2.5%). No significant difference was found when excluding PUD diagnosed within 2 years from GC. Conclusions: Our study provides innovative information on the mechanism of stomach mucosal damage leading to PUD and GC, with respect to the effect of tobacco smoking in particular.
- dc.format.mimetype application/pdf
- dc.identifier.citation Collatuzzo G, Alicandro G, Bertuccio P, Pelucchi C, Bonzi R, Palli D, et al. Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status, tobacco smoking, alcohol drinking and salt intake. J Epidemiol Community Health. 2022 Jul 13:jech-2022-219074. DOI: 10.1136/jech-2022-219074
- dc.identifier.doi http://dx.doi.org/10.1136/jech-2022-219074
- dc.identifier.issn 0143-005X
- dc.identifier.uri http://hdl.handle.net/10230/55811
- dc.language.iso eng
- dc.publisher BMJ Publishing Group
- dc.relation.ispartof J Epidemiol Community Health. 2022 Jul 13:jech-2022-219074
- dc.rights © BMJ Publishing Group http://dx.doi.org/10.1136/jech-2022-219074
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Alcohol
- dc.subject.keyword Gastric cancer
- dc.subject.keyword Mediation analysis
- dc.subject.keyword Peptic ulcer disease
- dc.subject.keyword Salt
- dc.subject.keyword Smoking
- dc.subject.keyword Socioeconomic status
- dc.title Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status, tobacco smoking, alcohol drinking and salt intake
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion