Blood neutrophil counts define specific clusters of bronchiectasis patients: A hint to differential clinical phenotypes

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• dc.contributor.author Wang, Xuejie
• dc.contributor.author Olveira, Casilda
• dc.contributor.author Girón, Rosa
• dc.contributor.author García-Clemente, Marta
• dc.contributor.author Máiz, Luis
• dc.contributor.author Sibila, Oriol
• dc.contributor.author Golpe, Rafael
• dc.contributor.author Menéndez, Rosario
• dc.contributor.author Rodríguez-López, Juan
• dc.contributor.author Prados, Concepción
• dc.contributor.author Martínez-González, Miguel Ángel, 1957-
• dc.contributor.author Rodriguez, Juan Luis
• dc.contributor.author Rosa, David de la
• dc.contributor.author Qin, Liyun
• dc.contributor.author Duran Jordà, Xavier, 1974-
• dc.contributor.author García Ojalvo, Jordi
• dc.contributor.author Barreiro Portela, Esther
• dc.date.accessioned 2022-06-17T05:51:47Z
• dc.date.available 2022-06-17T05:51:47Z
• dc.date.issued 2022
• dc.description.abstract We sought to investigate differential phenotypic characteristics according to neutrophil counts, using a biostatistics approach in a large-cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 1034 patients who met the inclusion criteria were clustered into two groups on the basis of their blood neutrophil levels. Using the Mann-Whitney U test to explore potential differences according to FACED and EFACED scores between the two groups, a neutrophil count of 4990 cells/µL yielded the most balanced cluster sizes: (1) above-threshold (n = 337) and (2) below-threshold (n = 697) groups. Patients above the threshold showed significantly worse lung function parameters and nutritional status, while systemic inflammation levels were higher than in the below-threshold patients. In the latter group, the proportions of patients with mild disease were greater, while a more severe disease was present in the above-threshold patients. According to the blood neutrophil counts using biostatistics analyses, two distinct clinical phenotypes of stable patients with non-CF bronchiectasis were defined. Patients falling into the above-threshold cluster were more severe. Severity was characterized by a significantly impaired lung function parameters and nutritional status, and greater systemic inflammation. Phenotypic profiles of bronchiectasis patients are well defined as a result of the cluster analysis of combined systemic and respiratory variables.
• dc.description.sponsorship This study has been supported by Project FIS 18/00075 funded by Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union; Project FIS 21/00215 funded by Instituto de Salud Carlos III and co-funded by the European Union; CIBERES 2021 funded by Instituto de Salud Carlos III (ISCIII); Sociedad Española de Neumología y Cirugía Torácica: SEPAR2020; Zambon (Spain): 2020; Ministerio de Ciencia y Tecnología: PGC 2018-101251-B-I00; Ministerio de Ciencia y Tecnología: CEX2018-000792-M.
• dc.format.mimetype application/pdf
• dc.identifier.citation Wang X, Olveira C, Girón R, García-Clemente M, Máiz L, Sibila O, Golpe R, Menéndez R, Rodríguez-López J, Prados C, Martinez-García MA, Rodriguez JL, de la Rosa D, Qin L, Duran X, Garcia-Ojalvo J, Barreiro E. Blood neutrophil counts define specific clusters of bronchiectasis patients: A hint to differential clinical phenotypes. Biomedicines. 2022 Apr 30;10(5):1044. DOI: 10.3390/biomedicines10051044
• dc.identifier.doi http://dx.doi.org/10.3390/biomedicines10051044
• dc.identifier.issn 2227-9059
• dc.identifier.uri http://hdl.handle.net/10230/53511
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Biomedicines. 2022 Apr 30;10(5):1044
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-101251-B-I00
• dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Biostatistics analyses
• dc.subject.keyword Bronchiectasis
• dc.subject.keyword Bronchiectasis severity scores
• dc.subject.keyword Clinical outcomes
• dc.subject.keyword Multivariate analyses
• dc.subject.keyword Neutrophilic inflammation
• dc.subject.keyword Phenotypic clusters
• dc.title Blood neutrophil counts define specific clusters of bronchiectasis patients: A hint to differential clinical phenotypes
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion