Thyroid function in early pregnancy, child IQ, and autistic traits: a meta-analysis of individual participant data

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Levie, Deborah
  • dc.contributor.author Korevaar, Tim I. M.
  • dc.contributor.author Bath, Sarah C.
  • dc.contributor.author Dalmau Bueno, Albert
  • dc.contributor.author Murcia, Mario
  • dc.contributor.author Espada Sáenz-Torre, Mercedes
  • dc.contributor.author Dineva, Mariana
  • dc.contributor.author Ibarluzea, Jesús
  • dc.contributor.author Sunyer Deu, Jordi
  • dc.contributor.author Tiemeier, Henning
  • dc.contributor.author Rebagliato, Marisa
  • dc.contributor.author Rayman, Margaret P.
  • dc.contributor.author Peeters, Robin P.
  • dc.contributor.author Guxens Junyent, Mònica
  • dc.date.accessioned 2019-07-23T08:30:15Z
  • dc.date.issued 2018
  • dc.description.abstract Context: Low maternal free T4 (FT4) has been associated with poor child neurodevelopment in some single-center studies. Evidence remains scarce for the potential adverse effects of high FT4 and whether associations differ in countries with different iodine status. Objective: To assess the association of maternal thyroid function in early pregnancy with child neurodevelopment in countries with a different iodine status. Design, Setting, and Participants: Meta-analysis of individual participant data from 9036 mother–child pairs from three prospective population-based birth cohorts: INMA [Infancia y Medio Ambiente (Environment and Childhood project) (Spain)], Generation R (Netherlands), and ALSPAC (Avon Longitudinal Study of Parents and Children, United Kingdom). The exclusion criteria were multiple pregnancies, fertility treatments, thyroid-interfering medication usage, and known thyroid disease. Main Outcomes: Child nonverbal IQ at 5 to 8 years of age, verbal IQ at 1.5 to 8 years of age, and autistic traits within the clinical range at 5 to 8 years of age. Results: FT4 <2.5th percentile was associated with a 3.9-point (95% CI, −5.7 to −2.2) lower nonverbal IQ and a 2.1-point (95% CI, −4.0 to −0.1) lower verbal IQ. A suggestive association of hypothyroxinemia with a greater risk of autistic traits was observed. FT4 >97.5th percentile was associated with a 1.9-fold (95% CI, 1.0 to 3.4) greater risk of autistic traits. No independent associations were found with TSH. Conclusions: Low maternal FT4 was consistently associated with a lower IQ across the cohorts. Further studies are needed to replicate the findings of autistic traits and investigate the potential modifying role of maternal iodine status. FT4 seems a reliable marker of fetal thyroid state in early pregnancy, regardless of the type of immunoassay.
  • dc.description.sponsorship EUthyroid Project: European Union’s Horizon 2020 research and innovation programme (grant 634453). INMA, Spain: This study was funded by grants from the European Union (grants FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1) and Spain: Instituto de Salud Carlos III (grants Red INMA G03/176, CB06/02/0041, FIS-FEDER: PI041436, PI05/1079, PI06/0867, PI081151, FIS- and PS09/00090, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687, and PI16/1288, Miguel Servet-FEDER CP11/00178, CP15/00025, and CPII16/00051, MS13/00054), Generalitat Valenciana: FISABIO (grants UGP 15-230, UGP-15-244, and UGP-15-249), Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació La Marató de TV3 (grants 090430), Department of Health of the Basque Government (grants 2005111093 and 2009111069), and the Provincial Government of Gipuzkoa (grants DFG06/004 and DFG08/001).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Levie D, Korevaar TIM, Bath SC, Dalmau-Bueno A, Murcia M, Espada M et al. Thyroid function in early pregnancy, child IQ, and autistic traits: a meta-analysis of individual participant data. J Clin Endocrinol Metab. 2018;103(8):2967-79. DOI: 10.1210/jc.2018-00224
  • dc.identifier.doi http://dx.doi.org/10.1210/jc.2018-00224
  • dc.identifier.issn 0021-972X
  • dc.identifier.uri http://hdl.handle.net/10230/42142
  • dc.language.iso eng
  • dc.publisher Endocrine Society
  • dc.relation.ispartof Journal of Clinical Endocrinology and Metabolism. 2018;103(8):2967-79
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634453
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
  • dc.rights © Endocrine Society http://dx.doi.org/10.1210/jc.2018-00224
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.title Thyroid function in early pregnancy, child IQ, and autistic traits: a meta-analysis of individual participant data
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

Col·leccions

Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Departament de Medicina i Ciències de la Vida)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)