Landscape of transcription in human cells
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- dc.contributor.author Djebali, Sarahca
- dc.contributor.author Merkel, Angelikaca
- dc.contributor.author Tanzer, Andreaca
- dc.contributor.author Lagarde, Julienca
- dc.contributor.author Röder, Maikca
- dc.contributor.author Curado, Joaoca
- dc.contributor.author Derrien, Thomasca
- dc.contributor.author Ferreira, Pedro G.ca
- dc.contributor.author González, Davidca
- dc.contributor.author Johnson, Roryca
- dc.contributor.author Kingswood, Colinca
- dc.contributor.author Ribeca, Paoloca
- dc.contributor.author Sammeth, Michaelca
- dc.contributor.author Skancke, Jorgenca
- dc.contributor.author Tilgner, Hagen, 1980-ca
- dc.contributor.author Guigó Serra, Rodericca
- dc.contributor.author Gingeras, Thomas R.ca
- dc.date.accessioned 2015-01-27T08:29:27Z
- dc.date.available 2015-01-27T08:29:27Z
- dc.date.issued 2012ca
- dc.description.abstract Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell's regulatory capabilities are focused on its synthesis, processing, transport, modification and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three-quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations, taken together, prompt a redefinition of the concept of a gene.
- dc.description.sponsorship This work was supported by the National Human Genome Research Institute (NHGRI) production grants U54HG004557, U54HG004555, U54HG004576 and U54HG004558, and by the NHGRI pilot grant R01HG003700. It was also supported by the NHGRI ARRA stimulus grant 1RC2HG005591, the National Science Foundation (SNF) grant 127375, the European Research Council (ERC) grant/n249968, a research grant for the RIKEN Omics Science Center from the Japanese Ministry of Education, Culture, Sports, Science and Technology, and grants BIO2011-26205, CSD2007-00050 and INB GNV-1 from the Spanish Ministry of Science
- dc.format.mimetype application/pdfca
- dc.identifier.citation Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, Mortazavi A et al. Landscape of transcription in human cells. Nature. 2012;489(7414):101-8. DOI: 10.1038/nature11233ca
- dc.identifier.doi http://dx.doi.org/10.1038/nature11233
- dc.identifier.issn 0028-0836ca
- dc.identifier.uri http://hdl.handle.net/10230/23073
- dc.language.iso engca
- dc.publisher Nature Publishing Groupca
- dc.relation.ispartof Nature. 2012;489(7414):101-8
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/249968
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/127375
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2011-26205
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/CSD2007-00050
- dc.rights This article is distributed under the terms of the Creative Commons Attribution-Non-Commercial-Share Alike licence http://dx.doi.org/10.1038/nature11247.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/
- dc.subject.other Genètica
- dc.subject.other Genoma humà
- dc.title Landscape of transcription in human cellsca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca