Genomic changes driving the acquisition of multidrug resistance in Candida glabrata

Księżopolska, Ewa

Genomic changes driving the acquisition of multidrug resistance in Candida glabrata

Document Type

Doctoral thesis
Published Version

Author

Księżopolska, Ewa

Director

Gabaldón Estevan, Juan Antonio

Publication Date

2021-07-05

Pages

232 p.

License

Citation

Księżopolska, E. Genomic changes driving the acquisition of multidrug resistance in Candida glabrata. 2021. handle: http://hdl.handle.net/10803/672386

This citation was generated automatically.

Doctoral program

Programa de doctorat en Biomedicina

Abstract

This project was set out to broaden our knowledge of the processes driving the emergence of antifungal drug resistance in an opportunistic yeast pathogen Candida glabrata. More precisely, we sought to find the mutational signatures of drug resistance and cross-resistance to representatives of two clinically important antifungal drug classes, azoles and echinocandins. By combining in vitro evolution with phenotypic screening and comparative genomics analysis we investigated the relationship between genomic changes, fitness and drug susceptibility to shed light on the cellular mechanisms and evolutionary constraints of antifungal drug resistance in this important pathogen