Primary results of the Spanish Cryoballoon Ablation Registry: acute and long-term outcomes of the RECABA study

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  • dc.contributor.author Ferrero-De-Loma-Osorio, Ángel
  • dc.contributor.author Cózar, Rocío
  • dc.contributor.author García-Alberola, Arcadio
  • dc.contributor.author Vallés Gras, Ermengol
  • dc.contributor.author Barrera, Alberto
  • dc.contributor.author Toquero, Jorge
  • dc.contributor.author Ormaetxe, Jose Miguel
  • dc.contributor.author Martínez Sánchez, Juan
  • dc.contributor.author Ruiz-Granell, Ricardo
  • dc.contributor.author Bastos Amador, Pablo
  • dc.contributor.author Rubio, José Manuel
  • dc.contributor.author Martí Almor, Julio
  • dc.contributor.author Pascual, Patricia
  • dc.contributor.author Molina, Irene
  • dc.contributor.author Martínez-Alday, Jesús Daniel
  • dc.contributor.author RECABA Investigators
  • dc.date.accessioned 2022-07-12T06:18:23Z
  • dc.date.available 2022-07-12T06:18:23Z
  • dc.date.issued 2021
  • dc.description.abstract Cryoablation is safe and effective for the treatment of atrial fibrillation (AF) in controlled clinical trials, but contemporary real-world usage and outcomes are limited. The Report of the Spanish Cryoballoon Ablation Registry (RECABA) was designed to evaluate acute and 12-month outcomes of cryoballoon ablation for the treatment of AF in Spain. Patients from 27 Spanish centers were prospectively enrolled. Patients were treated with cryoballoon ablation and managed according to standard of care protocols at each center. The primary endpoint was ≥ 30 s freedom from AF at 12-month after a 3-month blanking period. Secondary endpoints included a description of patient characteristics, cryoablation procedural strategy and safety, and predictors of efficacy. In total, 1742 patients (71.4% PAF, 68.8% male, mean age 58.02 ± 10.40 years, 76.1% overweight or obese, CHA2DS2-VASc index 1.40 ± 1.28) were enrolled. Patients received 7.2 ± 2.67 cryo-applications. PV potentials could be detected in 61% of the PVs during ablation, with a mean time to block of 52.9 ± 37.02 s. Acute PVI was observed in 97% of PVs with 75.8% isolated with the first cryo-application. Mean procedural time was 113 ± 41 min. Acute complications occurred in 4.4% of the cases. With follow-up in 1628 patients, AF-free survival was 78.5% (PAF: 80.6% vs PersAF 73.3%; p < 0.001). Left atrium enlargement, female sex, non-PAF, and early recurrence were independent predictors of AF recurrence (p < 0.05). RECABA provides detailed insight into current dosing practices and demonstrates cryoablation is safe and effective in real-world use.ClinicalTrials.gov number: NCT02785991.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Ferrero-De-Loma-Osorio Á, Cózar R, García-Alberola A, Valles E, Barrera A, Toquero J, et al. Primary results of the Spanish Cryoballoon Ablation Registry: acute and long-term outcomes of the RECABA study. Sci Rep. 2021 Aug 26; 11(1): 17268. DOI: 10.1038/s41598-021-96655-3
  • dc.identifier.doi http://dx.doi.org/10.1038/s41598-021-96655-3
  • dc.identifier.issn 2045-2322
  • dc.identifier.uri http://hdl.handle.net/10230/53716
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.rights Copyright © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Extirpació (Cirurgia)
  • dc.subject.other Cryoballoon Ablation
  • dc.subject.other Cirurgia
  • dc.title Primary results of the Spanish Cryoballoon Ablation Registry: acute and long-term outcomes of the RECABA study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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