Frailty among chronic kidney disease patients on the kidney transplant waiting list: the sex-frailty paradox

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• dc.contributor.author Pérez-Sáez, María José
• dc.contributor.author Arias Cabrales, Carlos Enrique
• dc.contributor.author Dávalos Yerovi, Vanesa
• dc.contributor.author Redondo Pachón, María Dolores
• dc.contributor.author Faura, Anna
• dc.contributor.author Vera, María
• dc.contributor.author Bach Pascual, Anna
• dc.contributor.author Pedreira Robles, Guillermo
• dc.contributor.author Junyent-Iglesias, Ernestina
• dc.contributor.author Crespo Barrio, Marta
• dc.contributor.author Marco, Ester
• dc.contributor.author Rodríguez-Mañas, Leocadio
• dc.contributor.author Pascual Santos, Julio
• dc.contributor.author FRAIL-MAR Study Group
• dc.date.accessioned 2022-08-31T07:43:24Z
• dc.date.available 2022-08-31T07:43:24Z
• dc.date.issued 2021
• dc.description.abstract Background: Frailty is defined as decreased physiologic reserve and resistance to stressors that predisposes patients towards poor health results. Its prevalence in chronic kidney disease (CKD) patients who are kidney transplant (KT) candidates is high. Frailty is associated with a higher rate of complications and mortality after transplant. It is unknown whether frailty phenotype differs depending on sex in this population. Methods: This was a prospective longitudinal study of 455 KT candidates evaluated for frailty by physical frailty phenotype at the time of inclusion on the KT waiting list. Pre-frailty was defined as the presence of two criteria and frailty as three or more criteria. Univariate and multivariate analyses searched for associations of frailty status, frailty components and gender differences. Results: Thirty percent of the total cohort resulted to be pre-frail (20%) or frail (10.3%), but disparities were observed between sexes, with 22.5% of men and 47.2% of women falling into one of these categories. Among frailty criteria, women presented with a higher percentage of exhaustion (39.6% versus 17%) and slowness (22.2% versus 9.6%) compared with men. Comorbidity burden was higher among frail men, whereas social factors were poorer between frail women. Disability was common among those patients who were frail, both men and women. Conclusions: Frailty is twice as frequent in advanced CKD women as men. Frailty criteria distribution and phenotype seem to differ among sexes, which might have implications in terms of specific and individualized interventions to improve their status before transplantation.
• dc.format.mimetype application/pdf
• dc.identifier.citation Pérez-Sáez MJ, Arias-Cabrales CE, Dávalos-Yerovi V, Redondo D, Faura A, Vera M, Bach A, Pedreira G, Junyent E, Crespo M, Marco E, Rodríguez-Mañas L, Pascual J; , for the FRAIL-MAR Study Group. Frailty among chronic kidney disease patients on the kidney transplant waiting list: the sex-frailty paradox. Clin Kidney J. 2021 Jul 10;15(1):109-18. DOI: 10.1093/ckj/sfab133
• dc.identifier.doi http://dx.doi.org/10.1093/ckj/sfab133
• dc.identifier.issn 2048-8505
• dc.identifier.uri http://hdl.handle.net/10230/53957
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof Clin Kidney J. 2021 Jul 10;15(1):109-18
• dc.rights © The Author(s) 2021. Published by Oxford University Press on behalf of ERA-EDTA. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Frailty
• dc.subject.keyword Gender
• dc.subject.keyword Kidney transplantation
• dc.subject.keyword Risk factor
• dc.subject.keyword Sex
• dc.title Frailty among chronic kidney disease patients on the kidney transplant waiting list: the sex-frailty paradox
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion