Association between ventilatory ratio and mortality in patients with acute respiratory distress syndrome and COVID 19: A multicenter, retrospective cohort study

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  • dc.contributor.author Parada-Gereda, Henry M.
  • dc.contributor.author Avendaño, Janneth M.
  • dc.contributor.author Melo, Johana E.
  • dc.contributor.author Ruiz, Claudia I.
  • dc.contributor.author Castañeda, Margarita I.
  • dc.contributor.author Medina-Parra, Jorge
  • dc.contributor.author Merchán Chaverra, Ricardo
  • dc.contributor.author Corzzo, Dinia
  • dc.contributor.author Molano Franco, Daniel
  • dc.contributor.author Masclans Enviz, Joan Ramon
  • dc.date.accessioned 2024-03-13T15:40:12Z
  • dc.date.available 2024-03-13T15:40:12Z
  • dc.date.issued 2023
  • dc.description.abstract Background: Mortality rates in patients with COVID-19 undergoing mechanical ventilation in the intensive care unit are high. The causes of this mortality have been rigorously investigated. The aim of the present study is to establish mortality risk factors related to lung mechanics measured at days 1 and 5 in patients with covid-19 ARDS managed with invasive mechanical ventilation in the intensive care unit. Methods: A retrospective observational multicenter study including consecutive patients with a confirmed diagnosis of COVID-19-induced ARDS, admitted to three institutions and seven intensive care units in the city of Bogota between May 20, 2020 and May 30, 2022 who required mechanical ventilation for at least five days. Data were collected from the medical records of patients who met the inclusion criteria on day 1 and day 5 of mechanical ventilation. The primary outcome assessed was mortality at day 30. Results: A total of 533 consecutive patients admitted with ARDS with COVID-19 were included. Ventilatory ratio, plateau pressure and driving pressure measured on day 5 were significantly higher in non-survivors (p < 0.05). Overall, 30-day follow-up mortality was 48.8%. The increases between day 1 and day 5 in the ventilatory ratio (OR 1.42, 95%CI 1.03-2.01, p = 0.04), driving pressure (OR 1.56, 95%CI 1.10-2.22, p = 0.01); and finally plateau pressure (OR 1.9, 95%CI 1.34-2.69, p = 0.001) were associated with an increased risk of death. There was no association between deterioration of PaO2/FIO2 index and mortality (OR 1.34, 95%CI 0.96-1.56, p = 0.053). Conclusions: Ventilatory ratio, plateau pressure, driving pressure, and age were identified as independent risk factors for 30-day mortality in patients with ARDS due to COVID-19 on day 5 of invasive mechanical ventilation.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Parada-Gereda HM, Avendaño JM, Melo JE, Ruiz CI, Castañeda MI, Medina-Parra J, Merchán-Chaverra R, Corzzo D, Molano-Franco D, Masclans JR. Association between ventilatory ratio and mortality in patients with acute respiratory distress syndrome and COVID 19: A multicenter, retrospective cohort study. BMC Pulm Med. 2023 Nov 3;23(1):425. DOI: 10.1186/s12890-023-02733-9
  • dc.identifier.doi http://dx.doi.org/10.1186/s12890-023-02733-9
  • dc.identifier.issn 1471-2466
  • dc.identifier.uri http://hdl.handle.net/10230/59401
  • dc.language.iso eng
  • dc.publisher BioMed Central
  • dc.relation.ispartof BMC Pulm Med. 2023 Nov 3;23(1):425
  • dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Artificial respiration
  • dc.subject.keyword COVID-19
  • dc.subject.keyword Mortality
  • dc.subject.keyword Respiratory distress syndrome
  • dc.subject.keyword Ventilatory ratio
  • dc.title Association between ventilatory ratio and mortality in patients with acute respiratory distress syndrome and COVID 19: A multicenter, retrospective cohort study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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