Delivery of a sebum modulator by an engineered skin microbe in mice

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• dc.contributor.author Knödlseder, Nastassia
• dc.contributor.author Fábrega, María José
• dc.contributor.author Santos Moreno, Javier
• dc.contributor.author Manils, Joan
• dc.contributor.author Toloza, Lorena
• dc.contributor.author Marín Vilar, Maria
• dc.contributor.author Fernández Avilés, Cristina
• dc.contributor.author Broadbent, Katrina
• dc.contributor.author Maruotti, Julien
• dc.contributor.author Lemenager, Hélène
• dc.contributor.author Carolis, Carlo
• dc.contributor.author Zouboulis, Christos C.
• dc.contributor.author Soler Prat, Concepció
• dc.contributor.author Lood, Rolf
• dc.contributor.author Brüggemann, Holger
• dc.contributor.author Güell Cargol, Marc, 1982-
• dc.date.accessioned 2024-05-29T16:13:17Z
• dc.date.issued 2024
• dc.description Data de publicació electrònica: 09-01-2024
• dc.description.abstract Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to create skin-delivered therapeutics. Here, we report the engineering of this bacterium to produce and secrete the therapeutic molecule neutrophil gelatinase-associated lipocalin, in vivo, for the modulation of cutaneous sebum production.
• dc.description.sponsorship This work was funded by the Office of Naval Research (award N62909-18-1-2155), INNOValora (INNOV21-09-1; SynFlora) given by Universitat Pompeu Fabra and Indústria del Coneixement of the Catalan government (AGAUR; IdC 2019 PROD 00057) and SKINDEV ‘Skin microbial devices’ by European Innovation Council (101098826), all granted to M.G., as well as by research grants PID2020-114477RB-I00 to C.S. and PID2021-126249OA-I00 to J.M. from the MCIN/AEI/10.13039/501100011033. N.K. is funded by a Maria Maetzu–UPF fellowship (AEI–MM-CEX2018-000792-M D.COMAS–Programa estatal de fomento investigación científica y técnica de exceléncia, unidades de exceléncia María de Maeztu 2018) and by the Sociedad Española de Químicos Cosméticos (Beca de la SEQC para la presentación de trabajos en el 33rd IFSCC Congress; KNÖDLSEDER, NASTASSIA). M.J.F. is funded by a Juan de la Cierva Fellowship from the Spanish government (award FJC 2018-037096-I). N.K. also received an EMBO short-term fellowship (fellowship no. 8240). J.S.M. is funded by a Marie Skłodowska-Curie Individual Fellowship (European Union’s Horizon 2020 Research and Innovation Program under Marie Skłodowska-Curie grant agreement 882387), a Juan de la Cierva Incorporación Fellowship (IJC2020-043621-I/MCIN/AEI/10.13039/501100011033 and NextGenerationEU/PRTR from the European Union) and a DCEXS MM Postdoc Project (Unidad de Excelencia María de Maeztu, funded by the AEI, ref. CEX2018-000792-M).
• dc.format.mimetype application/pdf
• dc.identifier.citation Knödlseder N, Fábrega MJ, Santos-Moreno J, Manils J, Toloza L, Marín Vilar M, et al. Delivery of a sebum modulator by an engineered skin microbe in mice. Nat Biotechnol. 2024 Jan 9. DOI: 10.1038/s41587-023-02072-4
• dc.identifier.doi http://dx.doi.org/10.1038/s41587-023-02072-4
• dc.identifier.issn 1087-0156
• dc.identifier.uri http://hdl.handle.net/10230/60285
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nat Biotechnol. 2024 Jan 9
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101098826
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-114477RB-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2021-126249OA-I00
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/882387
• dc.rights © Springer Nature Publishing AG [Knödlseder N, Fábrega MJ, Santos-Moreno J, Manils J, Toloza L, Marín Vilar M, et al. Delivery of a sebum modulator by an engineered skin microbe in mice. Nat Biotechnol. 2024 Jan 9. DOI: 10.1038/s41587-023-02072-4] [http://dx.doi.org/10.1038/s41587-023-02072-4]
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Applied microbiology
• dc.subject.keyword Genetic engineering
• dc.title Delivery of a sebum modulator by an engineered skin microbe in mice
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion